UniProt Accession

 SYUG_MOUSE; Q9Z0F7 

Genbank Protein ID

 AF017255; AF099986; AF099984; AF099985; BC028508 

Genbank Nucleotide ID

 AAC98893.1; AAD19899.1; AAD19899.1; AAD19899.1; AAH28508.1 

Protein Name

 Gamma-synuclein 

Protein Synonyms/Alias

 Persyn 

Gene Name

 Sncg 

Gene Synonyms/Alias

 Persyn 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	MYVGTKTKENVVQSV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). 

Sequence Annotation

 REPEAT 20 30 1.
 REPEAT 31 41 2.
 REPEAT 42 56 3; approximate.
 REPEAT 57 67 4.
 REGION 20 67 4 X 11 AA tandem repeats of [EGSA]-K-T-K-
 MOD_RES 120 120 Phosphoserine; by BARK1, CaMK2 and CK2  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 123 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0008344; P:adult locomotory behavior; IGI:MGI.
 GO:0002118; P:aggressive behavior; IEA:Compara.
 GO:0071464; P:cellular response to hydrostatic pressure; IEA:Compara.
 GO:0014059; P:regulation of dopamine secretion; IGI:MGI.
 GO:0046928; P:regulation of neurotransmitter secretion; IGI:MGI.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0050808; P:synapse organization; IGI:MGI.
 GO:0007268; P:synaptic transmission; IGI:MGI. 

Interpro

 IPR001058; Synuclein.
 IPR002462; Synuclein_gamma. 

Pfam

 PF01387; Synuclein 

SMART

  

PROSITE

  

PRINTS

 PR01214; GSYNUCLEIN.
 PR01211; SYNUCLEIN.