CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007320
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tat-binding homolog 7 
Protein Synonyms/Alias
  
Gene Name
 YTA7 
Gene Synonyms/Alias
 YGR270W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
194ISHSASSKRLKRANSacetylation[1]
1086GDRERVIKASEMFANubiquitination[2]
1210AIPSAVDKEKAVIPEacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
  
Sequence Annotation
 DOMAIN 1044 1086 Bromo; divergent.
 NP_BIND 454 461 ATP (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 212 212 Phosphothreonine.
 MOD_RES 229 229 Phosphothreonine.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 285 285 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 369 369 Phosphoserine.
 MOD_RES 370 370 Phosphoserine.
 MOD_RES 735 735 Phosphoserine.
 MOD_RES 1142 1142 Phosphoserine.
 MOD_RES 1256 1256 Phosphoserine.  
Keyword
 Acetylation; ATP-binding; Bromodomain; Complete proteome; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1379 AA 
Protein Sequence
MARNLRNRRG SDVEDASNAK VGYETQIKDE NGIIHTTTRS LRKINYAEIE KVFDFLEDDQ 60
VMDKDETPVD VTSDEHHNNN QKGDDEDDDV DLVSPHENAR TNEELTNERN LRKRKAHDPE 120
EDDESFHEED VDDDEEEEEA DEFEDEYLDE DSKDNNRRRR AADRKFVVPD PDDDEEYDED 180
DEEGDRISHS ASSKRLKRAN SRRTRSSRHP ETPPPVRRAL RSRTRHSRTS NEENDDENDN 240
SRNEALTLAD EIRELQEDSP IREKRFLRER TKPVNYKLPP PLTASNAEEF IDKNNNALSF 300
HNPSPARRGR GGWNASQNSG PTRRLFPTGG PFGGNDVTTI FGKNTNFYNQ VPSAFSDNNN 360
NKLILDSDSS DDEILPLGVT PKTKKENTQK KKKKKPEIAD LDPLGVDMNV NFDDIGGLDN 420
YIDQLKEMVA LPLLYPELYQ NFNITPPRGV LFHGPPGTGK TLMARALAAS CSSDERKITF 480
FMRKGADILS KWVGEAERQL RLLFEEAKKH QPSIIFFDEI DGLAPVRSSK QEQIHASIVS 540
TLLALMDGMD NRGQVIVIGA TNRPDAVDPA LRRPGRFDRE FYFPLPDVKA RFKILQIQTR 600
KWSSPLSTNF IDKLAFLTKG YGGADLRSLC TEAALISIQR SFPQIYRSND KLLVDPSKIK 660
VKVSDFMLAL KKIVPSSARS TGSSPQPLPE LIKPLLADQL NNLKNKLDYM LNIKDTTFQR 720
NTSLLQNFID YEEYSGEEEE HDKYGGNEDT SSFRSYEFFE SMAESQICKP RLLINGPKGN 780
GQQYVGAAIL NYLEEFNVQN LDLASLVSES SRTIEAAVVQ SFMEAKKRQP SVVFIPNLDI 840
WINTIPENVI LVLSGLFRSL QSNEKILLLC LAENLDISEV KNGILSDFAF DKNIFQLHKP 900
SKENITRYFS NLIELLKTKP SDIPMKKRRV KPLPELQKVT SNAAPTNFDE NGEPLSEKVV 960
LRRKLKSFQH QDMRLKNVLK IKLSGLMDLF KNRYKRFRKP PIDDAFLVHL FEPETSNDPN 1020
WQPAYIKDEN MILEVSTGRK FFNMDLDIVE ERLWNGYYSE PKQFLKDIEL IYRDANTIGD 1080
RERVIKASEM FANAQMGIEE ISTPDFIQEC KATRQRDLER QELFLEDEEK RAAMELEAKE 1140
QSQENILQEP DLKDNKANEF GVAAGNQLQA QLQTTINTAS IVNNSEVPQP IDTNLYKKEI 1200
PAAIPSAVDK EKAVIPEDSG ANEEYTTELI QATCTSEITT DDDERARKEP KENEDSLQTQ 1260
VTEENFSKID ANTNNINHVK EIQSVNKPNS LHETVEKRER SPIPKEVVEP EQGKKSDKEL 1320
ILTPEQIKKV SACLIEHCQN FTVSQLEDVH SSVAKIIWKS KSAWDKTGTV DEIIKFLSE 1379 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0042406; C:extrinsic to endoplasmic reticulum membrane; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IDA:SGD.
 GO:0042393; F:histone binding; IDA:SGD.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0031936; P:negative regulation of chromatin silencing; IMP:SGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR001487; Bromodomain.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA
 PF00439; Bromodomain 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2 
PRINTS