UniProt Accession

 B3KUK2_HUMAN; B3KUK2 

Genbank Protein ID

 AL135914; AK097395 

Genbank Nucleotide ID

 BAG53464.1 

Protein Name

 Superoxide dismutase 

Protein Synonyms/Alias

  

Gene Name

 SOD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	NLNVTEEKYQEALAK	acetylation	[1, 2]
76	GELLEAIKRDFGSFD	acetylation	[2]
84	RDFGSFDKFKEKLTA	acetylation	[1, 2]
84	RDFGSFDKFKEKLTA	ubiquitination	[3]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:Compara.
 GO:0004784; F:superoxide dismutase activity; IEA:EC.
 GO:0001306; P:age-dependent response to oxidative stress; IEA:Compara.
 GO:0071361; P:cellular response to ethanol; IEA:Compara.
 GO:0003032; P:detection of oxygen; IEA:Compara.
 GO:0048773; P:erythrophore differentiation; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0050665; P:hydrogen peroxide biosynthetic process; IEA:Compara.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0050790; P:regulation of catalytic activity; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0019430; P:removal of superoxide radicals; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0055093; P:response to hyperoxia; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0033591; P:response to L-ascorbic acid; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0010042; P:response to manganese ion; IEA:Compara.
 GO:0010269; P:response to selenium ion; IEA:Compara.
 GO:0034021; P:response to silicon dioxide; IEA:Compara.
 GO:0010043; P:response to zinc ion; IEA:Compara.
 GO:0042554; P:superoxide anion generation; IEA:Compara.
 GO:0003069; P:vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure; IEA:Compara. 

Interpro

 IPR001189; Mn/Fe_SOD.
 IPR019833; Mn/Fe_SOD_BS.
 IPR019832; Mn/Fe_SOD_C.
 IPR019831; Mn/Fe_SOD_N. 

Pfam

 PF02777; Sod_Fe_C
 PF00081; Sod_Fe_N 

SMART

  

PROSITE

 PS00088; SOD_MN 

PRINTS

 PR01703; MNSODISMTASE.