CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005865
UniProt Accession
Genbank Protein ID
 S87522 
Genbank Nucleotide ID
Protein Name
 Leukotriene A-4 hydrolase 
Protein Synonyms/Alias
 LTA-4 hydrolase; Leukotriene A(4) hydrolase 
Gene Name
 Lta4h 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
73VINGQEVKYTLGESQacetylation[1]
336CGRLFGEKFRHFHALacetylation[1]
370TKLVVDLKDVDPDVAacetylation[1]
518PLPLGHIKRMQEVYNacetylation[1]
565ATEQGRMKFTRPLFKacetylation[1]
572KFTRPLFKDLAAFDKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. 
Sequence Annotation
 REGION 135 137 Substrate binding (By similarity).
 REGION 266 271 Substrate binding (By similarity).
 REGION 563 565 Substrate binding (By similarity).
 ACT_SITE 296 296 Proton acceptor (By similarity).
 ACT_SITE 383 383 Proton donor (By similarity).
 METAL 295 295 Zinc; catalytic (By similarity).
 METAL 299 299 Zinc; catalytic (By similarity).
 METAL 318 318 Zinc; catalytic (By similarity).
 MOD_RES 73 73 N6-acetyllysine (By similarity).
 MOD_RES 336 336 N6-acetyllysine (By similarity).
 MOD_RES 413 413 N6-acetyllysine (By similarity).
 MOD_RES 415 415 Phosphoserine (By similarity).
 MOD_RES 572 572 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Leukotriene biosynthesis; Metal-binding; Metalloprotease; Phosphoprotein; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 610 AA 
Protein Sequence
MPEVEDTCSL ASPASVCRTQ HLHLRCSVDF ARRALTGTAA LTVQSQEDNL RTLTLDTKDL 60
TIEKVVINGQ EVKYTLGESQ GYKGSPMEIS LPIALSKNQE VVIEISFETS PKSSALQWLT 120
PEQTSGKQHP YLFSQWEAIH CRAILPCQDT SVKLTYTAEV SVPKELVALM SAIRDGEAPD 180
PEDPSRKIYR FNQRVPIPCY LIALVVGALE SRQIGPRTLV WSEKEQVEKS AYEFSETESM 240
LKIAEDLGGP YVWGQYDLLV LPPSFPYGGM ENPCLTFVTP TLLAGDKSLS NVIAHEISHS 300
WTGNLVTNKT WDHFWLNEGH TVYLERHICG RLFGEKFRHF HALGGWGELQ NTIKTFGESH 360
PFTKLVVDLK DVDPDVAYSS IPYEKGFALL FYLEQLLGGP EVFLGFLKAY VEKFSYQSVT 420
TDDWKSFLYA HFKDKVDLLN QVDWNAWLYA PGLPPVKPNY DVTLTNACIA LSQRWVTAKE 480
EDLNSFSIED LKDLSSHQLN EFLAQVLQRA PLPLGHIKRM QEVYNFNAIN NSEIRFRWLR 540
LCIQSKWEEA IPLALKMATE QGRMKFTRPL FKDLAAFDKS HDQAVRTYQE HKACMHPVTA 600
MLVGKDLKVD 610 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.
 GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.
 GO:0004463; F:leukotriene-A4 hydrolase activity; IDA:RGD.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.
 GO:0043171; P:peptide catabolic process; ISS:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
 GO:0010043; P:response to zinc ion; IEP:RGD.
 GO:0060509; P:Type I pneumocyte differentiation; IEP:RGD. 
Interpro
 IPR016024; ARM-type_fold.
 IPR012777; Leukotriene_A4_hydrolase.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 
Pfam
 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 
SMART
  
PROSITE
 PS00142; ZINC_PROTEASE 
PRINTS
 PR00756; ALADIPTASE.