CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025015
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel, subfamily H (Eag-related), member 1 
Protein Synonyms/Alias
  
Gene Name
 Kcnh1 
Gene Synonyms/Alias
 mCG_140652 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
174QLAPSVQKGENVHKHubiquitination[1]
524NSVRDFLKLYQVPKGubiquitination[1]
530LKLYQVPKGLSERVMubiquitination[1]
577HLNRKVFKEHPAFRLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Ion channel; Ion transport; Membrane; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 989 AA 
Protein Sequence
MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC KLSGYHRAEV 60
MQKSSACSFM YGELTDKDTV EKVRQTFENY EMNSFEILMY KKNRTPVWFF VKIAPIRNEQ 120
DKVVLFLCTF SDITAFKQPI EDDSCKGWGK FARLTRALTS SRGVLQQLAP SVQKGENVHK 180
HSRLAEVLQL GSDILPQYKQ EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS 240
FKTRQNNVAW LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL 300
LSCLPYDVIN AFENVDEVSA FMGDPGKIGF ADQIPPPLEG RESQGISSLF SSLKVVRLLR 360
LGRVARKLDH YIEYGAAVLV LLVCVFGLAA HWMACIWYSI GDYEIFDEDT KTIRNNSWLY 420
QLALDIGTPY QFNGSGSGKW EGGPSKNSVY ISSLYFTMTS LTSVGFGNIA PSTDIEKIFA 480
VAIMMIGSLL YATIFGNVTT IFQQMYANTN RYHEMLNSVR DFLKLYQVPK GLSERVMDYI 540
VSTWSMSRGI DTEKVLQICP KDMRADICVH LNRKVFKEHP AFRLASDGCL RALAMEFQTV 600
HCAPGDLIYH AGESVDSLCF VVSGSLEVIQ DDEVVAILGK GDVFGDVFWK EATLAQSCAN 660
VRALTYCDLH VIKRDALQKV LEFYTAFSHS FSRNLILTYN LRKRIVFRKI SDVKREEEER 720
MKRKNEAPLI LPPDHPVRRL FQRFRQQKEA RLAAERGGRD LDDLDVEKGN ALTDHTSANH 780
SLVKASVVTV RESPATPVSF QAATTSTVSD HAKLHAPGSE CLGPKAVSCD PAKRKGWARF 840
KDACGKGEDW NKVSKAESME TLPERTKAPG EATLKKTDSC DSGITKSDLR LDNVGETRSP 900
QDRSPILAEV KHSFYPIPEQ TLQATVLEVK YELKEDIKAL NAKMTSIEKQ LSEILRILMS 960
RGSAQSPQET GEISRPQSPE SDRDIFGAS 989 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. 
Interpro
 IPR018490; cNMP-bd-like.
 IPR000595; cNMP-bd_dom.
 IPR005821; Ion_trans_dom.
 IPR003949; K_chnl_volt-dep_EAG.
 IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR000700; PAS-assoc_C.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF00027; cNMP_binding
 PF00520; Ion_trans 
SMART
 SM00100; cNMP
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50042; CNMP_BINDING_3
 PS50113; PAC
 PS50112; PAS 
PRINTS
 PR01463; EAGCHANLFMLY.
 PR01464; EAGCHANNEL.