CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chaperone activity of bc1 complex-like, mitochondrial 
Protein Synonyms/Alias
 Chaperone-ABC1-like; aarF domain-containing protein kinase 3 
Gene Name
 Adck3 
Gene Synonyms/Alias
 Cabc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
188AKARPESKPHKQMLSacetylation[1]
191RPESKPHKQMLSERAubiquitination[2]
243SENSTGKKAVLDSSPubiquitination[2]
266RIVSTLCKVRGAALKubiquitination[2]
307SADFMPLKQMTKTLNacetylation[1]
311MPLKQMTKTLNSDLGacetylation[3]
311MPLKQMTKTLNSDLGubiquitination[2]
324LGPHWRDKLEYFEERacetylation[3, 4]
324LGPHWRDKLEYFEERubiquitination[2]
593NLIPVMLKHRLIPPPacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. 
Sequence Annotation
 DOMAIN 326 515 Protein kinase.  
Keyword
 Alternative splicing; ATP-binding; Chaperone; Complete proteome; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 645 AA 
Protein Sequence
MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELLLAA RALQSTAVEQ FSMVFGKVQG 60
QDKHEDSYAT ENFEDLEAEV QFSTPQAAGT SLDFSAASSL DQSLSPSHSQ GPAPAYASSG 120
PFREAGLPGQ ATSPMGRVNG RLFVDHRDLF LANGIQRRSF HQDQSSVGGL TAEDIEKARQ 180
AKARPESKPH KQMLSERARE RKVPVTRIGR LANFGGLAVG LGIGALAEVA KKSLRSENST 240
GKKAVLDSSP FLSEANAERI VSTLCKVRGA ALKLGQMLSI QDDAFINPHL AKIFERVRQS 300
ADFMPLKQMT KTLNSDLGPH WRDKLEYFEE RPFAAASIGQ VHLARMKGGR EVAMKIQYPG 360
VAQSINSDVN NLMAVLNMSN MLPEGLFPEH LIDVLRRELT LECDYQREAA YAKKFRELLK 420
DHPFFYVPEI VDELCSPHVL TTELISGFPL DQAEGLSQEV RNEICYNILV LCLRELFEFH 480
VMQTDPNWSN FFYDPQQHKV ALLDFGATRE YDRSFTDLYI QVIRAAADQD REAVLKKSIE 540
MKFLTGYEVK AMEDAHLDAI LILGEAFASE EPFDFGTQST TEKIHNLIPV MLKHRLIPPP 600
EETYSLHRKM GGSFLICSKL KARFPCKAMF EEAYSNYCRM KSGLQ 645 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR004147; UbiB_dom. 
Pfam
 PF03109; ABC1 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM 
PRINTS