UniProt Accession

 J3QPS8_MOUSE; J3QPS8 

Genbank Protein ID

 AL596185 

Genbank Nucleotide ID

  

Protein Name

 Eukaryotic translation initiation factor 5A-1 

Protein Synonyms/Alias

  

Gene Name

 Eif5a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	LPEGDLGKEIEQKYD	acetylation	[1, 2]
43	LPEGDLGKEIEQKYD	succinylation	[2]
43	LPEGDLGKEIEQKYD	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 76 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0043022; F:ribosome binding; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:InterPro.
 GO:0007568; P:aging; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0008612; P:peptidyl-lysine modification to hypusine; IEA:InterPro.
 GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
 GO:0051149; P:positive regulation of muscle cell differentiation; IEA:Compara.
 GO:0045901; P:positive regulation of translational elongation; IEA:InterPro.
 GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
 GO:0006452; P:translational frameshifting; IEA:InterPro. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR001884; Transl_elong_IF5A.
 IPR020189; Transl_elong_IF5A_C. 

Pfam

 PF01287; eIF-5a 

SMART

  

PROSITE

  

PRINTS