CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019757
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oncostatin-M-specific receptor subunit beta 
Protein Synonyms/Alias
 Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB 
Gene Name
 OSMR 
Gene Synonyms/Alias
 OSMRB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
209SVPFIRNKGTNIYCEubiquitination[1]
251SCETEDFKTLHCTWDubiquitination[1]
269DTALGWSKQPSQSYTubiquitination[1]
787SSILSLIKFKENPHLubiquitination[1, 2, 3, 4]
834LTETELTKPNYLYLLubiquitination[1, 3, 5, 6]
895TSPENVLKALEKNYMubiquitination[6]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. 
Sequence Annotation
 DOMAIN 332 424 Fibronectin type-III 1.
 DOMAIN 430 524 Fibronectin type-III 2.
 DOMAIN 526 619 Fibronectin type-III 3.
 DOMAIN 625 732 Fibronectin type-III 4.
 MOTIF 415 419 WSXWS motif.
 MOTIF 770 778 Box 1 motif.
 MOD_RES 826 826 Phosphoserine.
 MOD_RES 889 889 Phosphoserine.
 CARBOHYD 163 163 N-linked (GlcNAc...) (Potential).
 CARBOHYD 326 326 N-linked (GlcNAc...) (Potential).
 CARBOHYD 380 380 N-linked (GlcNAc...) (Potential).
 CARBOHYD 446 446 N-linked (GlcNAc...) (Potential).
 CARBOHYD 580 580 N-linked (GlcNAc...) (Potential).
 DISULFID 245 255 By similarity.  
Keyword
 Alternative splicing; Amyloidosis; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 979 AA 
Protein Sequence
MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL QWTVHNLPYH 60
QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE SELPLECATH FVRIKSLVDD 120
AKFPEPNFWS NWSSWEEVSV QDSTGQDILF VFPKDKLVEE GTNVTICYVS RNIQNNVSCY 180
LEGKQIHGEQ LDPHVTAFNL NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP 240
KDFSCETEDF KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ 300
DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI MTWKVHSIRN 360
NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY MARVRCADAS HFWKWSEWSG 420
QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT LFWKPLSKLH ANGKILFYNV VVENLDKPSS 480
SELHSIPAPA NSTKLILDRC SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE 540
GGFSLSWKPQ PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR 600
IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST ESQPGFIQGY 660
HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI VDNLKPESFY EFFITPFTSA 720
GEGPSATFTK VTTPDEHSSM LIHILLPMVF CVLLIMVMCY LKSQWIKETC YPDIPDPYKS 780
SILSLIKFKE NPHLIIMNVS DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL 840
LPTEKNHSGP GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN 900
YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA VSLRLALPPP 960
TENSSLSSIT LLDPGEHYC 979 
Gene Ontology
 GO:0005900; C:oncostatin-M receptor complex; IDA:BHF-UCL.
 GO:0004924; F:oncostatin-M receptor activity; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0002675; P:positive regulation of acute inflammatory response; IC:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR003529; Hematopoietin_rcpt_Gp130_CS.
 IPR013783; Ig-like_fold. 
Pfam
 PF00041; fn3 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01353; HEMATOPO_REC_L_F2 
PRINTS