CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HLA class II histocompatibility antigen gamma chain 
Protein Synonyms/Alias
  
Gene Name
 CD74 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
154LKVYPPLKGSFPENLubiquitination[1]
165PENLRHLKNTMETIDubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 316 AA 
Protein Sequence
XRSCREDQKP VMDDQRDLIS NNEQLPMLGR RPGAPESKCS RGALYTGFSI LVTLLLAGQA 60
TTAYFLYQQQ GRLDKLTVTS QNLQLENLRM KLPKPPKPVS KMRMATPLLM QALPMGALPQ 120
GPMQNATKYG NMTEDHVMHL LQNADPLKVY PPLKGSFPEN LRHLKNTMET IDWKVFESWM 180
HHWLLFEMSR HSLEQKPTDA PPKVLTKCQE EVSHIPAVHP GSFRPKCDEN GNYLPLQCYG 240
SIGYCWCVFP NGTEVPNTRS RGHHNCSESL ELEDPSSGLG VTKQDLGPGK GLAEGHLVTS 300
SSSPAGPAPL WAGEGV 316 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
 IPR022339; MHC_II-assoc_invar_chain.
 IPR011988; MHC_II-assoc_invariant_trimer.
 IPR000716; Thyroglobulin_1. 
Pfam
 PF09307; MHC2-interact
 PF08831; MHCassoc_trimer
 PF00086; Thyroglobulin_1 
SMART
 SM00211; TY 
PROSITE
 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 
PRINTS
 PR01990; CD74ANTIGEN.