Tag | Content |
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CPLM ID | CPLM-024588 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2A.J |
Protein Synonyms/Alias | H2a/j |
Gene Name | H2afj |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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6 | **MSGRGKQGGKVRA | acetylation | [1] | 10 | GRGKQGGKVRAKAKS | acetylation | [1] | 37 | RVHRLLRKGNYAERV | acetylation | [1] | 96 | RNDEELNKLLGRVTI | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Sequence Annotation | MOD_RES 2 2 N-acetylserine (By similarity). MOD_RES 2 2 Phosphoserine (By similarity). MOD_RES 6 6 N6-acetyllysine (By similarity). MOD_RES 121 121 Phosphothreonine (By similarity). CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly) CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 129 AA |
Protein Sequence | MSGRGKQGGK VRAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 60 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK 120 TESQKVKSK 129 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |