UniProt Accession

 NAB1_HUMAN; Q13506; O75383; O75384; Q6GTU1; Q9UEV1 

Genbank Protein ID

 U47007; AF045451; AF045452; AC006460; BC035724; AF052744 

Genbank Nucleotide ID

 AAC50588.1; AAC25085.1; AAC25086.1; AAX93076.1; AAH35724.1; AAC28325.1 

Protein Name

 NGFI-A-binding protein 1 

Protein Synonyms/Alias

 EGR-1-binding protein 1; Transcriptional regulatory protein p54 

Gene Name

 NAB1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
355	LFQQARAKSEELAAL	ubiquitination	[1]
480	TLEKKVIKTEPEDSR	sumoylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634] 

Functional Description

 Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity). 

Sequence Annotation

 REGION 4 82 NCD1.
 REGION 221 310 NCD2.
 REGION 307 338 Necessary for nuclear localization (By
 MOD_RES 328 328 Phosphoserine.
 MOD_RES 403 403 Phosphoserine (By similarity).
 CROSSLNK 333 333 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 480 480 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 487 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0042552; P:myelination; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0045682; P:regulation of epidermis development; IEA:Compara.
 GO:0014037; P:Schwann cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006986; Nab1_C.
 IPR006989; NAB_co-repressor_dom.
 IPR006988; Nab_N. 

Pfam

 PF04902; Nab1
 PF04904; NCD1
 PF04905; NCD2 

SMART

  

PROSITE

  

PRINTS