UniProt Accession

 OXSM_MOUSE; Q9D404 

Genbank Protein ID

 AK016905; AK083617; AK084829 

Genbank Nucleotide ID

 BAB30490.1; BAC38969.1; BAC39286.1 

Protein Name

 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 

Protein Synonyms/Alias

 Beta-ketoacyl-ACP synthase 

Gene Name

 Oxsm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
109	NEENFVSKSDAKSMS	acetylation	[1]
138	KDSGWHPKREADQVA	acetylation	[1]
174	FQTKGYNKVSPFFVP	acetylation	[1]
261	LSSNPDPKLACRPFH	acetylation	[1, 2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function (By similarity). 

Sequence Annotation

 MOD_RES 174 174 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Acyltransferase; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 459 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; ISS:HGNC.
 GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; ISS:HGNC.
 GO:0006637; P:acyl-CoA metabolic process; ISS:HGNC.
 GO:0051792; P:medium-chain fatty acid biosynthetic process; ISS:HGNC.
 GO:0051790; P:short-chain fatty acid biosynthetic process; ISS:HGNC. 

Interpro

 IPR017568; 3-oxoacyl-ACP_synth-2.
 IPR018201; Ketoacyl_synth_AS.
 IPR014031; Ketoacyl_synth_C.
 IPR014030; Ketoacyl_synth_N.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 

Pfam

 PF00109; ketoacyl-synt
 PF02801; Ketoacyl-synt_C 

SMART

  

PROSITE

 PS00606; B_KETOACYL_SYNTHASE 

PRINTS