CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000434
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tumor protein p73 
Protein Synonyms/Alias
 p53-like transcription factor; p53-related protein 
Gene Name
 TP73 
Gene Synonyms/Alias
 P73 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321ALNESSAKNGAASKRacetylation[1, 2]
327AKNGAASKRAFKQSPacetylation[1, 2]
331AASKRAFKQSPPAVPacetylation[1]
345PALGAGVKKRRHGDEubiquitination[3]
Reference
 [1] DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.
 Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole PA, Fontemaggi G, Fanciulli M, Schiltz L, Blandino G, Balsano C, Levrero M.
 Mol Cell. 2002 Jan;9(1):175-86. [PMID: 11804596]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. 
Sequence Annotation
 DOMAIN 485 551 SAM.
 REGION 1 46 Transactivation (By similarity).
 REGION 131 310 DNA-binding (Potential).
 REGION 345 386 Oligomerization (Potential).
 REGION 345 380 Interaction with HIPK2.
 MOTIF 483 487 WW-binding.
 METAL 194 194 Zinc (By similarity).
 METAL 197 197 Zinc (By similarity).
 METAL 258 258 Zinc (By similarity).
 METAL 262 262 Zinc (By similarity).
 MOD_RES 27 27 Phosphothreonine; by PLK1.
 MOD_RES 28 28 Phosphotyrosine; by SRC and HCK.
 MOD_RES 99 99 Phosphotyrosine; by ABL1.
 CROSSLNK 627 627 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Activator; Alternative promoter usage; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 636 AA 
Protein Sequence
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 60
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 120
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 180
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 240
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR 300
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR 360
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG 420
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH 480
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT 540
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 600
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH 636 
Gene Ontology
 GO:0000785; C:chromatin; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003684; F:damaged DNA binding; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0002039; F:p53 binding; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0034644; P:cellular response to UV; IBA:RefGenome.
 GO:0033326; P:cerebrospinal fluid secretion; IEA:Compara.
 GO:0048546; P:digestive tract morphogenesis; IEA:Compara.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:RefGenome.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:UniProtKB.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0006298; P:mismatch repair; TAS:ProtInc.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IBA:RefGenome.
 GO:0043508; P:negative regulation of JUN kinase activity; IBA:RefGenome.
 GO:0043524; P:negative regulation of neuron apoptotic process; IBA:RefGenome.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045793; P:positive regulation of cell size; IEA:Compara.
 GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051262; P:protein tetramerization; IEA:InterPro.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IBA:RefGenome.
 GO:0010243; P:response to organic nitrogen; IEA:Compara.
 GO:0010165; P:response to X-ray; IBA:RefGenome.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR011615; p53_DNA-bd.
 IPR010991; p53_tetrameristn.
 IPR002117; p53_tumour_suppressor.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2. 
Pfam
 PF00870; P53
 PF07710; P53_tetramer
 PF07647; SAM_2 
SMART
 SM00454; SAM 
PROSITE
 PS00348; P53
 PS50105; SAM_DOMAIN 
PRINTS
 PR00386; P53SUPPRESSR.