CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000260
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Segment polarity protein dishevelled homolog DVL-1 
Protein Synonyms/Alias
 Dishevelled-1; DSH homolog 1 
Gene Name
 DVL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
285IYIGSIMKGGAVAADubiquitination[1]
337PISLTVAKCWDPTPRubiquitination[1]
469KERREARKYASSLLKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). 
Sequence Annotation
 DOMAIN 1 85 DIX.
 DOMAIN 251 323 PDZ.
 DOMAIN 425 499 DEP.
 MOD_RES 559 559 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Membrane; Phosphoprotein; Reference proteome; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 695 AA 
Protein Sequence
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK 60
EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF 120
HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST 180
ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI 240
TDSTMSLNIV TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP RADPVRPIDP 360
AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG APQLEEAPLT VKSDMSAVVR 420
VMQLPDSGLE IRDRMWLKIT IANAVIGADV VDWLYTHVEG FKERREARKY ASSLLKHGFL 480
RHTVNKITFS EQCYYVFGDL CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY 540
QYPGPPPCFP PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS 600
GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA YTVVGGPPGG 660
PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM 695 
Gene Ontology
 GO:0030424; C:axon; IBA:RefGenome.
 GO:0005938; C:cell cortex; IBA:RefGenome.
 GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IBA:RefGenome.
 GO:0030426; C:growth cone; IBA:RefGenome.
 GO:0005874; C:microtubule; IBA:RefGenome.
 GO:0043025; C:neuronal cell body; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; ISS:BHF-UCL.
 GO:0048365; F:Rac GTPase binding; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0048675; P:axon extension; IBA:RefGenome.
 GO:0007411; P:axon guidance; IBA:RefGenome.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.
 GO:0048668; P:collateral sprouting; IBA:RefGenome.
 GO:0060026; P:convergent extension; IBA:RefGenome.
 GO:0022007; P:convergent extension involved in neural plate elongation; IEA:Compara.
 GO:0031122; P:cytoplasmic microtubule organization; IEA:Compara.
 GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0006469; P:negative regulation of protein kinase activity; IDA:BHF-UCL.
 GO:0021915; P:neural tube development; IEP:BHF-UCL.
 GO:0007269; P:neurotransmitter secretion; ISS:BHF-UCL.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0060134; P:prepulse inhibition; IEA:Compara.
 GO:0035372; P:protein localization to microtubule; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IMP:BHF-UCL.
 GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. 
Interpro
 IPR000591; DEP_dom.
 IPR008340; Dishevelled_1.
 IPR024580; Dishevelled_C-dom.
 IPR008339; Dishevelled_fam.
 IPR003351; Dishevelled_protein_dom.
 IPR001158; DIX.
 IPR015506; Dsh/Dvl-rel.
 IPR001478; PDZ.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF02377; Dishevelled
 PF00778; DIX
 PF12316; Dsh_C
 PF00595; PDZ 
SMART
 SM00021; DAX
 SM00049; DEP
 SM00228; PDZ 
PROSITE
 PS50186; DEP
 PS50841; DIX
 PS50106; PDZ 
PRINTS
 PR01760; DISHEVELLED.