CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019964
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone acetyltransferase KAT5 
Protein Synonyms/Alias
 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; Lysine acetyltransferase 5 
Gene Name
 Kat5 
Gene Synonyms/Alias
 Htatip; Tip60; Tip60b 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
104ASAQASGKTLPIPVQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM (By similarity). 
Sequence Annotation
 ZN_FING 261 283 C2HC-type.
 REGION 377 383 Acetyl-CoA binding (By similarity).
 ACT_SITE 327 327 By similarity.
 ACT_SITE 369 369 Nucleophile (By similarity).
 BINDING 372 372 Acetyl-CoA (By similarity).
 BINDING 407 407 Acetyl-CoA (By similarity).
 MOD_RES 52 52 N6-acetyllysine (By similarity).
 MOD_RES 86 86 Phosphoserine (By similarity).
 MOD_RES 90 90 Phosphoserine (By similarity).
 MOD_RES 327 327 N6-acetyllysine; by autocatalysis (By
 CROSSLNK 430 430 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 451 451 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Activator; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 513 AA 
Protein Sequence
MAEVGEIIEG CRLPVLRRNQ DNEDEWPLAE ILSVKDISGR KLFYVHYIDF NKRLDEWVTH 60
ERLDLKKIQF PKKEAKTPTK NGLPGSRPGS PEREVPASAQ ASGKTLPIPV QITLRFNLPK 120
EREAIPGGEP DQPLSSSSCL QPNHRSTKRK VEVVSPATPV PSETAPASVF PQNGSARRAV 180
AAQPGRKRKS NCLGTDEDSQ DSSDGIPSAP RMTGSLVSDR SHDDIVTRMK NIECIELGRH 240
RLKPWYFSPY PQELTTLPVL YLCEFCLKYG RSLKCLQRHL TKCDLRHPPG NEIYRKGTIS 300
FFEIDGRKNK SYSQNLCLLA KCFLDHKTLY YDTDPFLFYV MTEYDCKGFH IVGYFSKEKE 360
STEDYNVACI LTLPPYQRRG YGKLLIEFSY ELSKVEGKTG TPEKPLSDLG LLSYRSYWSQ 420
TILEILMGLK SESGERPQIT INEISEITSI KKEDVISTLQ YLNLINYYKG QYILTLSEDI 480
VDGHERAMLK RLLRIDSKCL HFTPKDWSKR GKW 513 
Gene Ontology
 GO:0000785; C:chromatin; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; NAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:RGD.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ISS:UniProtKB.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0043967; P:histone H4 acetylation; NAS:UniProtKB.
 GO:0032703; P:negative regulation of interleukin-2 production; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR002717; MOZ_SAS.
 IPR025995; Tudor-knot. 
Pfam
 PF01853; MOZ_SAS
 PF11717; Tudor-knot 
SMART
 SM00298; CHROMO 
PROSITE
  
PRINTS