UniProt Accession

 CD9_HUMAN; P21926; D3DUQ9; Q5J7W6; Q96ES4 

Genbank Protein ID

 M38690; L34068; X60111; S60489; S60462; S60463; S60464; S60700; S60699; S60465; S60472; L08118; L08119; L08120; L08121; L08122; L08123; L08124; L08125; AB079244; AY423720; AY422198; CH471116; CH471116; BC011988 

Genbank Nucleotide ID

 AAA80320.1; AAA59982.1; CAA42708.1; AAC60586.1; AAC60586.1; AAC60586.1; AAC60586.1; AAC60586.1; AAC60586.1; AAC60586.1; AAC60586.1; AAA51954.1; AAA51955.1; AAA51956.1; AAA51957.1; AAA51958.1; AAA51959.1; BAE71132.1; AAS00483.1; AAQ87878.1; EAW88812.1; EAW88813.1; AAH11988.1 

Protein Name

 CD9 antigen 

Protein Synonyms/Alias

 5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24; CD9 

Gene Name

 CD9 

Gene Synonyms/Alias

 MIC3; TSPAN29; GIG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	KEVQEFYKDTYNKLK	ubiquitination	[1]
131	FYKDTYNKLKTKDEP	ubiquitination	[1]
133	KDTYNKLKTKDEPQR	ubiquitination	[1]
135	TYNKLKTKDEPQRET	ubiquitination	[1]
170	ISDICPKKDVLETFT	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. 

Sequence Annotation

 LIPID 9 9 S-palmitoyl cysteine (Probable).
 LIPID 78 78 S-palmitoyl cysteine (Probable).
 LIPID 79 79 S-palmitoyl cysteine (Probable).
 LIPID 87 87 S-palmitoyl cysteine (Probable).
 LIPID 218 218 S-palmitoyl cysteine (Probable).
 LIPID 219 219 S-palmitoyl cysteine (Probable).
 CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).
 CARBOHYD 53 53 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Fertilization; Glycoprotein; Lipoprotein; Membrane; Palmitate; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0031092; C:platelet alpha granule membrane; TAS:Reactome.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007155; P:cell adhesion; IDA:UniProtKB.
 GO:0006928; P:cellular component movement; IDA:UniProtKB.
 GO:0007342; P:fusion of sperm to egg plasma membrane; IDA:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0030913; P:paranodal junction assembly; ISS:UniProtKB.
 GO:0030168; P:platelet activation; NAS:UniProtKB.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0009414; P:response to water deprivation; IEA:Compara. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.