CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022830
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family D member 2 
Protein Synonyms/Alias
 Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR 
Gene Name
 ABCD2 
Gene Synonyms/Alias
 ALD1; ALDL1; ALDR; ALDRP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
517TGPNGCGKSSLFRILubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Probable transporter. 
Sequence Annotation
 DOMAIN 107 399 ABC transmembrane type-1.
 DOMAIN 478 704 ABC transporter.
 NP_BIND 511 518 ATP (Potential).
 REGION 1 218 Interaction with PEX19.
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Peroxisome; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 740 AA 
Protein Sequence
MTHMLNAAAD RVKWTRSSAA KRAACLVAAA YALKTLYPII GKRLKQSGHG KKKAAAYPAA 60
ENTEILHCTE TICEKPSPGV NADFFKQLLE LRKILFPKLV TTETGWLCLH SVALISRTFL 120
SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW LMIAIPATFV NSAIRYLECK LALAFRTRLV 180
DHAYETYFTN QTYYKVINMD GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVMLTSY 240
TLIQTATSRG ASPIGPTLLA GLVVYATAKV LKACSPKFGK LVAEEAHRKG YLRYVHSRII 300
ANVEEIAFYR GHKVEMKQLQ KSYKALADQM NLILSKRLWY IMIEQFLMKY VWSSSGLIMV 360
AIPIITATGF ADGEDGQKQV MVSERTEAFT TARNLLASGA DAIERIMSSY KEVTELAGYT 420
ARVYNMFWVF DEVKRGIYKR TAVIQESESH SKNGAKVELP LSDTLAIKGK VIDVDHGIIC 480
ENVPIITPAG EVVASRLNFK VEEGMHLLIT GPNGCGKSSL FRILSGLWPV YEGVLYKPPP 540
QHMFYIPQRP YMSLGSLRDQ VIYPDSVDDM HDKGYTDQDL ERILHNVHLY HIVQREGGWD 600
AVMDWKDVLS GGEKQRMGMA RMFYHKPKYA LLDECTSAVS IDVEGKIFQA AKGAGISLLS 660
ITHRPSLWKY HTHLLQFDGE GGWRFEQLDT AIRLTLSEEK QKLESQLAGI PKMQQRLNEL 720
CKILGEDSVL KTIKNEDETS 740 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; TAS:Reactome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006635; P:fatty acid beta-oxidation; IGI:UniProtKB.
 GO:0032000; P:positive regulation of fatty acid beta-oxidation; IDA:UniProtKB.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0042760; P:very long-chain fatty acid catabolic process; IGI:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR010509; ABC_Ald_N.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06472; ABC_membrane_2
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS