CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045335
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 18 
Protein Synonyms/Alias
  
Gene Name
 ARHGEF18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
280FQERLSMKDQLIAQSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 812 AA 
Protein Sequence
XRMKEKYGVF CSGHNEAVSH YKLLLQQNKK FQNLIKKIGN FSIVRRLGVQ ECILLVTQRI 60
TKYPVLVERI IQNTEAGTED YEDLTQALNL IKDIISQVDA KVSECEKGQR LREIAGKMDL 120
KSSSKLKNGL TFRKEDMLQR QLHLEGMLCW KTTSGRLKDI LAILLTDVLL LLQEKDQKYV 180
FASVDSKPPV ISLQKLIVRE VANEEKAMFL ISASLQGPEM YEIYTSSKED RNAWMAHIQR 240
AVESCPDEEE GPFSLPEEER KVVEARATRL RDFQERLSMK DQLIAQSLLE KQQIYLEMAE 300
MGGLEDLPQP RGLFRGGDPS ETLQGELILK SAMSEIEGIQ SLICRQLGSA NGQAEDGGSS 360
TGPPRRAETF AGYDCTNSPT KNGSFKKKVS STDPRPRDWR GPPNSPDLKL SDSDIPGSSE 420
ESPQVVEAPG TESDPRLPTV LESELVQRIQ TLSQLLLNLQ DSYVETQRAA IQEREKQFRL 480
QSTRGNLLLE QERQRNFEKQ REERAALEKL QSQLRHEQQR WERERQWQHQ ELERAGARLQ 540
EREGEARQLR ERLEQERAEL ERQRQAYQHD LERLREAQRA VERERERLEL LRRLKKQNTA 600
PGALPPDTLA EAQPPSHPPS FNGEGLEGPR VSMLPSGVGP EYAERPEVAR RDSAPTENRL 660
AKSDVPIQLL SATNQFQRQA AVQQQIPTKL AASTKGGKDK GGKSRGSQRW ESSASFDLKQ 720
QLLLNKLMGK DESTSRNRRS LSPILPGRHS PAPPPDPGFP APSPPPADSP SEGFSLKAGG 780
TALLPGPPAP SPLPATPLSA KEDASKEDVI FF 812 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015721; RhoGEF-like. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00233; PH 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS