UniProt Accession

 HPPK_ECOLI; P26281 

Genbank Protein ID

 L06495; M20574; U00096; AP009048 

Genbank Nucleotide ID

 AAB53446.1; AAC73253.1; BAB96719.1 

Protein Name

 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 

Protein Synonyms/Alias

 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK 

Gene Name

 folK 

Gene Synonyms/Alias

 b0142; JW0138 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
155	LHTRAFDKLNKW***	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

  

Keyword

 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Folate biosynthesis; Kinase; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IDA:EcoCyc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000550; Hppk. 

Pfam

 PF01288; HPPK 

SMART

  

PROSITE

 PS00794; HPPK 

PRINTS