CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transmembrane protease serine 3 
Protein Synonyms/Alias
  
Gene Name
 TMPRSS3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
97CDGVSDCKDGEDEYRubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MGENDPPAVE APFSFRSLFG LDDLKISPVA PDAVAAQILS LLPLKFFPII VIGIIALILA 60
LAIGLGIHFD CSGKYRCRSS FKCIELIARC DGVSDCKDGE DEYRCVRVGG QNAVLQVFTA 120
ASWKTMCSDD WKGHYANVAC AQLGFPSYVS SDNLRVSSLE GQFREEFVSI DHLLPDDKVT 180
ALHHSVYVRE GCASGHVVTL QCTACGHRRG YSSRIVGGNM SLLSQWPWQA SLQFQGYHLC 240
GGSVITPLWI ITAAHCVYDL YLPKSWTIQV GLVSLLDNPA PSHLVEKIVY HSKYKPKRLG 300
NDIALMKLAG PLTFNEMIQP VCLPNSEENF PDGKVCWTSG WGATEDGGDA SPVLNHAAVP 360
LISNKICNHR DVYGGIISPS MLCAGYLTGG VDSCQGDSGG PLVCQERRLW KLVGATSFGI 420
GCAEVNKPGV YTRVTSFLDW IHEQMERDLK T 451 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR001190; Srcr_rcpt.
 IPR017448; Srcr_rcpt-rel.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00057; Ldl_recept_a
 PF00530; SRCR
 PF00089; Trypsin 
SMART
 SM00192; LDLa
 SM00202; SR
 SM00020; Tryp_SPc 
PROSITE
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS00420; SRCR_1
 PS50287; SRCR_2
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.