| Tag | Content |
|---|
| CPLM ID | CPLM-000258 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 195 |
Protein Synonyms/Alias | |
Gene Name | ZNF195 |
Gene Synonyms/Alias | ZNFP104 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | ITCLEQRKEPWNVKR | ubiquitination | [1] | | 70 | RKEPWNVKRQEAADG | ubiquitination | [1] | | 101 | GIQDAFPKRILRGYG | ubiquitination | [1] | | 119 | LDNLYLRKDWESLDE | ubiquitination | [1] | | 128 | WESLDECKLQKDYNG | ubiquitination | [1] | | 131 | LDECKLQKDYNGLNQ | ubiquitination | [1] | | 146 | CSSTTHSKIFQYNKY | ubiquitination | [1] | | 152 | SKIFQYNKYVKIFDN | ubiquitination | [1] | | 174 | NISNTGEKPFKCQEC | ubiquitination | [1] | | 177 | NTGEKPFKCQECGKS | ubiquitination | [1] | | 230 | ENIDTGEKPYKCQEC | ubiquitination | [1] | | 242 | QECNNVIKTCSVLTK | ubiquitination | [1] | | 249 | KTCSVLTKNRIYAGG | ubiquitination | [1] | | 315 | LAGEKLSKCETWYKG | ubiquitination | [1] | | 340 | QRNEIGGKPFKCEEC | ubiquitination | [1] | | 343 | EIGGKPFKCEECDSI | ubiquitination | [1] | | 359 | KWFSDLTKHKRIHTG | ubiquitination | [1] | | 396 | RRIHTGEKPYQCEEC | ubiquitination | [1] | | 405 | YQCEECGKVFRTCSS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation. |
Sequence Annotation | DOMAIN 4 75 KRAB.
ZN_FING 244 266 C2H2-type 1.
ZN_FING 272 294 C2H2-type 2; degenerate.
ZN_FING 410 432 C2H2-type 3.
ZN_FING 438 460 C2H2-type 4.
ZN_FING 466 488 C2H2-type 5.
ZN_FING 494 516 C2H2-type 6.
ZN_FING 522 544 C2H2-type 7.
ZN_FING 550 572 C2H2-type 8.
ZN_FING 578 600 C2H2-type 9.
ZN_FING 606 628 C2H2-type 10.
REGION 76 243 Spacer.
MOD_RES 408 408 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 629 AA |
Protein Sequence | MAGAQTLLTF RDVAIEFSLE EWKCLDLAQQ NLYRDVMLEN YRNLFSVGLT VCKPGLITCL 60
EQRKEPWNVK RQEAADGHPA MSSHFTQDLL PEQGIQDAFP KRILRGYGNC GLDNLYLRKD 120
WESLDECKLQ KDYNGLNQCS STTHSKIFQY NKYVKIFDNF SNLHRRNISN TGEKPFKCQE 180
CGKSFQMLSF LTEHQKIHTG KKFQKCGECG KTFIQCSHFT EPENIDTGEK PYKCQECNNV 240
IKTCSVLTKN RIYAGGEHYR CEEFGKVFNQ CSHLTEHEHG TEEKPCKYEE CSSVFISCSS 300
LSNQQMILAG EKLSKCETWY KGFNHSPNPS KHQRNEIGGK PFKCEECDSI FKWFSDLTKH 360
KRIHTGEKPY KCDECGKAYT QSSHLSEHRR IHTGEKPYQC EECGKVFRTC SSLSNHKRTH 420
SEEKPYTCEE CGNIFKQLSD LTKHKKTHTG EKPYKCDECG KNFTQSSNLI VHKRIHTGEK 480
PYKCEECGRV FMWFSDITKH KKTHTGEKPY KCDECGKNFT QSSNLIVHKR IHTGEKPYKC 540
EKCGKAFTQF SHLTVHESIH T 561 |
Gene Ontology | GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0008270; F:zinc ion binding; NAS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |