CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor coactivator 2 
Protein Synonyms/Alias
  
Gene Name
 Ncoa2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
78AILKETVKQIRQIKEacetylation[1]
640HESKGQTKLLQLLTTacetylation[1]
713LTAEATGKELNQESSacetylation[1]
751LLRYLLDKDDTKDIGacetylation[1]
765GLPEITPKLERLDSKacetylation[1]
772KLERLDSKTDPASNTacetylation[1]
780TDPASNTKLIAMKTVacetylation[1]
785NTKLIAMKTVKEEVSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1465 AA 
Protein Sequence
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA ELIFANFNDI 60
DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS DVSSTGQGVI DKDALGPMML 120
EALDGFFFVV NLEGNVVFVS ENVTQYLRYN QEELMNKSVY SILHVGDHTE FVKNLLPKSM 180
VNGGSWTGEP PRRNSHTFNC RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE 240
EGEDLQSCLI CVARRVPMKE RPALPSSESF TTRQDLQGKI TSLDTSTMRA AMKPGWEDLV 300
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ TKSKLIRSQT 360
TNEPQLVISL HMLHREQNVC VMNPDLTGQA MGKPLSPMSS SSPARQAMCS GNPGQDVALG 420
SNMNFPMNGP REQMSMPMGR FGGSGGMNHV SGMQATTPQG SNYALKMNSP SQSSPGLNPG 480
QPSSVLSPRH RMSPGVAGSP RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL 540
SEGHGVSLGP SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 600
EASCHPEEQK RPNDSSMPQA ASGDRAEGHS RLHESKGQTK LLQLLTTKSD QMEPSPLPSS 660
LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP VDLAKLTAEA TGKELNQESS 720
GTAPGSEVTV KQEPASPKKK ENALLRYLLD KDDTKDIGLP EITPKLERLD SKTDPASNTK 780
LIAMKTVKEE VSFEPSDQPG SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII 840
NDLMQLTADS SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 900
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP SGEWAPQSPA 960
VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ MLQPQVMNIG PSELEMNMGG 1020
PQYNQQQAPP NQTAPWPESI LPIDQASFGS QNRHPFGSSP DDLLCPHPAA ESPSDEGALL 1080
DQLYLALRNF DGLEEIDRAL GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ 1140
TQMAQGSYNP MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 1200
QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR QMHQQQQVQQ 1260
RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP FPPNYGISQQ PDPGFTGATT 1320
PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA SDMNGWAQGS MGGNSMFSQQ SPPHFGQQAN 1380
TSMYNNNMNI NVSMATNTAG LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS 1440
SLFTTNQLPG MDMIKQEGDG SRKFC 1465 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom.
 IPR010011; DUF1518.
 IPR009110; Nuc_rcpt_coact.
 IPR014920; Nuc_rcpt_coact_Ncoa-typ.
 IPR017426; Nuclear_rcpt_coactivator.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR014935; SRC-1.
 IPR008955; Src1_rcpt_coact. 
Pfam
 PF07469; DUF1518
 PF08815; Nuc_rec_co-act
 PF00989; PAS
 PF08832; SRC-1 
SMART
 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50112; PAS 
PRINTS