| Tag | Content |
|---|
| CPLM ID | CPLM-002006 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement component C9 |
Protein Synonyms/Alias | Complement component C9a; Complement component C9b |
Gene Name | C9 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 378 | GVELKDIKRCLGYHL | ubiquitination | [1] | | 483 | IYNLVPVKMKNAHLK | ubiquitination | [1] | | 485 | NLVPVKMKNAHLKKQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. |
Sequence Annotation | DOMAIN 42 95 TSP type-1.
DOMAIN 99 136 LDL-receptor class A.
DOMAIN 138 509 MACPF.
DOMAIN 510 540 EGF-like.
CARBOHYD 48 48 C-linked (Man).
CARBOHYD 51 51 C-linked (Man); partial.
CARBOHYD 277 277 N-linked (GlcNAc...).
CARBOHYD 415 415 N-linked (GlcNAc...).
DISULFID 43 78
DISULFID 54 57
DISULFID 88 94
DISULFID 101 112
DISULFID 107 125
DISULFID 119 134
DISULFID 142 181
DISULFID 254 255
DISULFID 380 405
DISULFID 510 526
DISULFID 513 528
DISULFID 530 539 |
Keyword | Cell membrane; Complement alternate pathway; Complement pathway; Complete proteome; Cytolysis; Direct protein sequencing; Disease mutation; Disulfide bond; EGF-like domain; Glycoprotein; Immunity; Innate immunity; Membrane; Membrane attack complex; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane beta strand. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 559 AA |
Protein Sequence | MSACRSFAVA ICILEISILT AQYTTSYDPE LTESSGSASH IDCRMSPWSE WSQCDPCLRQ 60
MFRSRSIEVF GQFNGKRCTD AVGDRRQCVP TEPCEDAEDD CGNDFQCSTG RCIKMRLRCN 120
GDNDCGDFSD EDDCESEPRP PCRDRVVEES ELARTAGYGI NILGMDPLST PFDNEFYNGL 180
CNRDRDGNTL TYYRRPWNVA SLIYETKGEK NFRTEHYEEQ IEAFKSIIQE KTSNFNAAIS 240
LKFTPTETNK AEQCCEETAS SISLHGKGSF RFSYSKNETY QLFLSYSSKK EKMFLHVKGE 300
IHLGRFVMRN RDVVLTTTFV DDIKALPTTY EKGEYFAFLE TYGTHYSSSG SLGGLYELIY 360
VLDKASMKRK GVELKDIKRC LGYHLDVSLA FSEISVGAEF NKDDCVKRGE GRAVNITSEN 420
LIDDVVSLIR GGTRKYAFEL KEKLLRGTVI DVTDFVNWAS SINDAPVLIS QKLSPIYNLV 480
PVKMKNAHLK KQNLERAIED YINEFSVRKC HTCQNGGTVI LMDGKCLCAC PFKFEGIACE 540
ISKQKISEGL PALEFPNEK 559 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005576; C:extracellular region; TAS:Reactome. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW. GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0019835; P:cytolysis; IEA:UniProtKB-KW. GO:0019836; P:hemolysis by symbiont of host erythrocytes; TAS:ProtInc. GO:0045087; P:innate immune response; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |