| Tag | Content |
|---|
| CPLM ID | CPLM-023284 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inactive phospholipase C-like protein 2 |
Protein Synonyms/Alias | PLC-L(2); PLC-L2; Phospholipase C-L2; Phospholipase C-epsilon-2; PLC-epsilon-2 |
Gene Name | PLCL2 |
Gene Synonyms/Alias | KIAA1092; PLCE2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 131 | FSSMPTEKKISSASD | acetylation | [1] | | 132 | SSMPTEKKISSASDC | acetylation | [1] | | 150 | MVEGSELKKVRSNSR | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum (By similarity). |
Sequence Annotation | DOMAIN 141 251 PH.
DOMAIN 426 570 PI-PLC X-box.
DOMAIN 618 734 PI-PLC Y-box.
DOMAIN 741 846 C2.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 17 17 Phosphoserine.
MOD_RES 584 584 Phosphothreonine.
MOD_RES 1113 1113 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Transducer. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1127 AA |
Protein Sequence | MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD SGGVSNGDCS 60
LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG LPRRSSIIKD GTKQKRERKK 120
TVSFSSMPTE KKISSASDCI NSMVEGSELK KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD 180
SEKAKIDIKS IKEVRTGKNT DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN 240
IWVTGLRYLI SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN 300
PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ FSSNKEFLDT 360
KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL SIDGFTNYLM SPDCYIFDPE 420
HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF RGPSDITGYI RALKMGCRSV ELDVWDGPDN 480
EPVIYTGHTM TSQIVFRSVI DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG 540
DKLYTTSPNV EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN 600
MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE VLASKYANEN 660
PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV AMNFQTPGLM MDLNIGWFRQ 720
NGNCGYVLRP AIMREEVSFF SANTKDSVPG VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD 780
PYVYVEIHGI PADCAEQRTK TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE 840
FIGQYTIPFE CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK 900
KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL SSVANLMQCM 960
LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI VTTYDMMIQS LKALIENADA 1020
VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE RKLQKAVESF TWNITILKGQ ADLLKYAKNE 1080
TLENLKQIHF AAVSCGLNKP GTENADVQKP RRSLEVIPEK ANDETGE 1127 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0006629; P:lipid metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |