UniProt Accession

 VATC1_HUMAN; P21283 

Genbank Protein ID

 X69151; AF363578; BC010960; J05682 

Genbank Nucleotide ID

 CAA48903.1; AAL50383.1; AAH10960.1; AAA36803.1 

Protein Name

 V-type proton ATPase subunit C 1 

Protein Synonyms/Alias

 V-ATPase subunit C 1; Vacuolar proton pump subunit C 1 

Gene Name

 ATP6V1C1 

Gene Synonyms/Alias

 ATP6C; ATP6D; VATC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	KLHAATSKNNNLAVT	ubiquitination	[1]
71	FVEGVVKKVAQYMAD	ubiquitination	[2]
137	TQIDNDLKSRASAYN	ubiquitination	[1]
147	ASAYNNLKGNLQNLE	ubiquitination	[1, 2, 3, 4, 5, 6]
156	NLQNLERKNAGSLLT	ubiquitination	[5]
245	RHKARENKFIVRDFQ	ubiquitination	[5]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 382 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0016469; C:proton-transporting two-sector ATPase complex; TAS:ProtInc.
 GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Compara.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; TAS:ProtInc.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0033572; P:transferrin transport; TAS:Reactome. 

Interpro

 IPR004907; ATPase_V1-cplx_csu. 

Pfam

 PF03223; V-ATPase_C 

SMART

  

PROSITE

  

PRINTS