UniProt Accession

 KCNB1_MOUSE; Q03717; Q8K0D1 

Genbank Protein ID

 M64228; AL591854; AL591711; AL591711; AL591854; CH466551; BC031776; BC061501 

Genbank Nucleotide ID

 AAA40112.1; CAM13429.1; CAM13429.1; CAM17304.1; CAM17304.1; EDL06500.1; AAH31776.1; AAH61501.1 

Protein Name

 Potassium voltage-gated channel subfamily B member 1 

Protein Synonyms/Alias

 Voltage-gated potassium channel subunit Kv2.1; mShab 

Gene Name

 Kcnb1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
451	SIVSMNMKDAFARSI	ubiquitination	[1]
474	KNGEGVAKKDKVQDN	sumoylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.
 Plant LD, Dowdell EJ, Dementieva IS, Marks JD, Goldstein SA.
 J Gen Physiol. 2011 May;137(5):441-54. [PMID: 21518833] 

Functional Description

 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. 

Sequence Annotation

 MOTIF 377 382 Selectivity filter (By similarity).
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 15 15 Phosphoserine (By similarity).
 MOD_RES 128 128 Phosphotyrosine; by Src (By similarity).
 MOD_RES 457 457 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine (By similarity).
 MOD_RES 496 496 Phosphoserine (By similarity).
 MOD_RES 503 503 Phosphoserine (By similarity).
 MOD_RES 520 520 Phosphoserine (By similarity).
 MOD_RES 541 541 Phosphoserine (By similarity).
 MOD_RES 567 567 Phosphoserine (By similarity).
 MOD_RES 590 590 Phosphoserine (By similarity).
 MOD_RES 607 607 Phosphoserine (By similarity).
 MOD_RES 655 655 Phosphoserine.
 MOD_RES 719 719 Phosphoserine (By similarity).
 MOD_RES 771 771 Phosphoserine (By similarity).
 MOD_RES 799 799 Phosphoserine (By similarity).
 MOD_RES 804 804 Phosphoserine (By similarity).
 MOD_RES 836 836 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 857 AA 

Protein Sequence

Gene Ontology

 GO:0030425; C:dendrite; IEA:Compara.
 GO:0032590; C:dendrite membrane; IEA:Compara.
 GO:0032809; C:neuronal cell body membrane; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:Compara.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0015271; F:outward rectifier potassium channel activity; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003973; K_chnl_volt-dep_Kv2.
 IPR004350; K_chnl_volt-dep_Kv2.1.
 IPR003131; T1-type_BTB. 

Pfam

 PF00520; Ion_trans
 PF02214; K_tetra
 PF03521; Kv2channel 

SMART

 SM00225; BTB 

PROSITE

  

PRINTS

 PR00169; KCHANNEL.
 PR01514; KV21CHANNEL.
 PR01491; KVCHANNEL.
 PR01495; SHABCHANNEL.