UniProt Accession

 INGR1_HUMAN; P15260; E1P587; Q53Y96 

Genbank Protein ID

 J03143; AY594694; BT006814; AL050337; CH471051; CH471051; BC005333 

Genbank Nucleotide ID

 AAA52731.1; AAS89302.1; AAP35460.1; CAB53062.1; EAW47931.1; EAW47932.1; AAH05333.1 

Protein Name

 Interferon gamma receptor 1 

Protein Synonyms/Alias

 IFN-gamma receptor 1; IFN-gamma-R1; CDw119; CD119 

Gene Name

 IFNGR1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	QKESAYAKSEEFAVC	ubiquitination	[1]
279	KINPLKEKSIILPKS	ubiquitination	[2, 3]
285	EKSIILPKSLISVVR	ubiquitination	[1, 2, 3, 4, 5, 6, 7]
299	RSATLETKPESKYVS	ubiquitination	[1, 5, 7]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. 

Sequence Annotation

 MOD_RES 369 369 Phosphoserine (By similarity).
 MOD_RES 372 372 Phosphothreonine (By similarity).
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
 CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 DISULFID 77 85
 DISULFID 122 167
 DISULFID 195 200
 DISULFID 214 235  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 489 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004906; F:interferon-gamma receptor activity; TAS:ProtInc.
 GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0009615; P:response to virus; TAS:ProtInc. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR021126; Interferon_gamma_pox/mammal.
 IPR008355; Interferon_gamma_rcpt_asu. 

Pfam

 PF07140; IFNGR1 

SMART

  

PROSITE

  

PRINTS

 PR01777; INTERFERONGR.