UniProt Accession

 LS14A_HUMAN; Q8ND56; Q76LX7; Q96AR3; Q96K73; Q96SN5; Q9UFR3 

Genbank Protein ID

 AB069974; AB069975; AK027369; AK027643; AL834398; AL117499; BC016842 

Genbank Nucleotide ID

 BAC99045.1; BAC99046.1; BAB55066.1; BAB55259.1; CAD39060.2; CAB55964.1; AAH16842.1 

Protein Name

 Protein LSM14 homolog A 

Protein Synonyms/Alias

 Protein FAM61A; Protein SCD6 homolog; Putative alpha-synuclein-binding protein; AlphaSNBP; RNA-associated protein 55A; hRAP55; hRAP55A 

Gene Name

 LSM14A 

Gene Synonyms/Alias

 C19orf13; FAM61A; RAP55; RAP55A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	GTPYIGSKISLISKA	ubiquitination	[1]
174	TQDTRSLKTQLSQGR	ubiquitination	[1]
291	IRRDGPMKFEKDFDF	acetylation	[2]
294	DGPMKFEKDFDFESA	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. 

Sequence Annotation

 DOMAIN 284 320 DFDF.
 MOTIF 361 377 FFD box.
 MOTIF 380 400 TFG box.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 192 192 Phosphoserine.
 MOD_RES 194 194 Phosphothreonine.
 MOD_RES 216 216 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Ribonucleoprotein; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0033962; P:cytoplasmic mRNA processing body assembly; IDA:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 

Interpro

 IPR025762; DFDF.
 IPR019050; FDF_dom.
 IPR025761; FFD_box.
 IPR025609; Lsm14_N.
 IPR010920; LSM_dom.
 IPR025768; TFG_box. 

Pfam

 PF09532; FDF
 PF12701; LSM14 

SMART

  

PROSITE

 PS51512; DFDF
 PS51513; FFD
 PS51536; TFG 

PRINTS