UniProt Accession

 H7C3C5_HUMAN; H7C3C5 

Genbank Protein ID

 AC015982 

Genbank Nucleotide ID

  

Protein Name

 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 PNPT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	SIVLNEYKRCDGRDL	ubiquitination	[1]
70	SCEVDMFKTLHGSAL	ubiquitination	[1]
111	ITAINGIKDKNFMLH	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 139 AA 

Protein Sequence

Gene Ontology

 GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
 GO:0004654; F:polyribonucleotide nucleotidyltransferase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006402; P:mRNA catabolic process; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 

Interpro

 IPR001247; ExoRNase_PH_dom1.
 IPR012162; PNPase.
 IPR027408; PNPase/RNase_PH_dom.
 IPR015848; PNPase_PH_RNA-bd_bac/org-type.
 IPR020568; Ribosomal_S5_D2-typ_fold. 

Pfam

 PF03726; PNPase
 PF01138; RNase_PH 

SMART

  

PROSITE

  

PRINTS