UniProt Accession

 S10AA_MOUSE; P08207 

Genbank Protein ID

 M16465; BC025044 

Genbank Nucleotide ID

 AAA37363.1; AAH25044.1 

Protein Name

 Protein S100-A10 

Protein Synonyms/Alias

 Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; S100 calcium-binding protein A10; p10 protein; p11 

Gene Name

 S100a10 

Gene Synonyms/Alias

 Cal1l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
23	FHRFAGDKDHLTKED	acetylation	[1]
28	GDKDHLTKEDLRVLM	acetylation	[2]
47	PGFLENQKDPLAVDK	acetylation	[3]
47	PGFLENQKDPLAVDK	ubiquitination	[4]
54	KDPLAVDKIMKDLDQ	acetylation	[2]
54	KDPLAVDKIMKDLDQ	ubiquitination	[4]
57	LAVDKIMKDLDQCRD	acetylation	[2]
57	LAVDKIMKDLDQCRD	ubiquitination	[4]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase. 

Sequence Annotation

 REGION 60 71 Ancestral calcium site.
 MOD_RES 23 23 N6-acetyllysine (By similarity).
 MOD_RES 28 28 N6-acetyllysine (By similarity).
 MOD_RES 54 54 N6-acetyllysine (By similarity).
 MOD_RES 57 57 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 97 AA 

Protein Sequence

Gene Ontology

 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0071229; P:cellular response to acid; IDA:MGI.
 GO:0051099; P:positive regulation of binding; IMP:MGI. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR001751; S100/CaBP-9k_CS.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS