UniProt Accession

 ORAI2_HUMAN; Q96SN7; Q6IA68; Q8WY94; Q9H9Y3 

Genbank Protein ID

 AK027639; AC093668; AC093668; BC069270; AF258552; CR457287 

Genbank Nucleotide ID

 BAB55256.1; AAP22351.1; AAP22352.1; AAH69270.1; AAG23755.1; CAG33568.1 

Protein Name

 Protein orai-2 

Protein Synonyms/Alias

 CAP-binding protein complex-interacting protein 2; Transmembrane protein 142B 

Gene Name

 ORAI2 

Gene Synonyms/Alias

 C7orf19; CBCIP2; TMEM142B; PP1729 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	ACPEPGHKGMDYRDW	ubiquitination	[1]
52	VQALSWRKLYLSRAK	ubiquitination	[1]
239	REIEELHKLKVQLDG	ubiquitination	[1, 2]
241	IEELHKLKVQLDGHE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR012446; CRAC_channel. 

Pfam

 PF07856; Orai-1 

SMART

  

PROSITE

  

PRINTS