CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glutamate receptor ionotropic, NMDA 2A 
Protein Synonyms/Alias
  
Gene Name
 GRIN2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
723GVHIEEKKKSPDFNLmethylation[1]
781IMDMVSDKGNLMYSDubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1124 AA 
Protein Sequence
MLKIMQDYDW HVFSLVTTIF PGYREFISFV KTTVDNSFVG WDMQNVITLD TSFEDAKTQV 60
QLKKIHSSVI LLYCSKDEAV LILSEARSLG LTGYDFFWIV PSLVSGNTEL IPKEFPSGLI 120
SVSYDDWDYS LEARVRDGIG ILTTAASSML EKFSYIPEAK ASCYGQMERP EVPMHTLHPF 180
MVNVTWDGKD LSFTEEGYQV HPRLVVIVLN KDREWEKVGK WENHTLSLRH AVWPRYKSFS 240
DCEPDDNHLS IVTLEEAPFV IVEDIDPLTE TCVRNTVPCR KFVKINNSTN EGMNVKKCCK 300
GFCIDILKKL SRTVKFTYDL YLVTNGKHGK KVNNVWNGMI GEVVYQRAVM AVGSLTINEE 360
RSEVVDFSVP FVETGISVMV SRSNGTVSPS AFLEPFSASV WVMMFVMLLI VSAIAVFVFE 420
YFSPVGYNRN LAKGKAPHGP SFTIGKAIWL LWGLVFNNSV PVQNPKGTTS KIMVSVWAFF 480
AVIFLASYTA NLAAFMIQEE FVDQVTGLSD KKFQRPHDYS PPFRFGTVPN GSTERNIRNN 540
YPYMHQYMTK FNQKGVEDAL VSLKTGKLDA FIYDAAVLNY KAGRDEGCKL VTIGSGYIFA 600
TTGYGIALQK GSPWKRQIDL ALLQFVGDGE MEELETLWLT GICHNEKNEV MSSQLDIDNM 660
AGVFYMLAAA MALSLITFIW EHLFYWKLRF CFTGVCSDRP GLLFSISRGI YSCIHGVHIE 720
EKKKSPDFNL TGSQSNMLKL LRSAKNISSM SNMNSSRMDS PKRAADFIQR GSLIMDMVSD 780
KGNLMYSDNR SFQGKESIFG DNMNELQTFV ANRQKDNLNN YVFQGQHPLT LNESNPNTVE 840
VAVSTESKAN SRPRQLWKKS VDSIRQDSLS QNPVSQRDEA TAENRTHSLK SPRYLPEEMA 900
HSDISETSNR ATCHREPDNS KNHKTKDNFK RSVASKYPKD CSEVERTYLK TKSSSPRDKI 960
YTIDGEKEPG FHLDPPQFVE NVTLPENVDF PDPYQDPSEN FRKGDSTLPM NRNPLHNEEG 1020
LSNNDQYKLY SKHFTLKDKG SPHSETSERY RQNSTHCRSC LSNMPTYSGH FTMRSPFKCD 1080
ACLRMGNLYD IDEDQMLQET GMTNAWLLGD APRTLTNTRC HPRR 1124 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
 GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:GOC. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR018884; NMDAR2_C.
 IPR001638; SBP_bac_3. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10565; NMDAR2_C
 PF00497; SBP_bac_3 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.