UniProt Accession

 AN32A_MOUSE; O35381; P97437 

Genbank Protein ID

 U73478; AF022957; BC062899 

Genbank Nucleotide ID

 AAB39707.1; AAB91546.1; AAH62899.1 

Protein Name

 Acidic leucine-rich nuclear phosphoprotein 32 family member A 

Protein Synonyms/Alias

 Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; LANP; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A 

Gene Name

 Anp32a 

Gene Synonyms/Alias

 Anp32; Lanp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
20	NRTPSDVKELVLDNC	ubiquitination	[1]
28	ELVLDNCKSIEGKIE	ubiquitination	[1]
68	PKLNKLKKLELSENR	ubiquitination	[1]
86	DLEVLAEKCPNLKHL	ubiquitination	[1]
91	AEKCPNLKHLNLSGN	ubiquitination	[1]
99	HLNLSGNKIKDLSTI	ubiquitination	[1]
101	NLSGNKIKDLSTIEP	ubiquitination	[1]
137	AYRENVFKLLPQVMY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. 

Sequence Annotation

 REPEAT 18 38 LRR 1.
 REPEAT 43 64 LRR 2.
 REPEAT 65 87 LRR 3.
 REPEAT 89 110 LRR 4.
 DOMAIN 123 161 LRRCT.
 REGION 150 172 Necessary for tumor-suppressive function
 REGION 165 247 Interaction with E4F1.
 MOD_RES 15 15 Phosphothreonine (By similarity).
 MOD_RES 17 17 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Endoplasmic reticulum; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0016363; C:nuclear matrix; IPI:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 

Pfam

 PF12799; LRR_4 

SMART

 SM00446; LRRcap 

PROSITE

 PS51450; LRR 

PRINTS