CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinamide nucleotide transhydrogenase 
Protein Synonyms/Alias
 Protein Nnt 
Gene Name
 Nnt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
49LWCKSPAKPGIPYKQacetylation[1]
55AKPGIPYKQLTVGVPacetylation[1]
63QLTVGVPKEIFQNEKacetylation[1]
70KEIFQNEKRVALSPAacetylation[1]
84AGVQALVKQGFNVVVacetylation[1]
100SGAGEASKFPDDLYRacetylation[1]
117GAQIQGTKEVLASDLacetylation[1]
146AHEADFLKPSGTLISacetylation[1]
229AGKVPPAKILIVGGGacetylation[1]
294GYAKEMSKEFIEAEMacetylation[1]
323STALIPGKKAPVLFSacetylation[1]
331KAPVLFSKEMIESMKacetylation[1]
358GGNFETTKPGELYVHacetylation[1]
394LYSNNITKLLKAISPacetylation[1]
397NNITKLLKAISPDKDacetylation[1]
403LKAISPDKDNFHFEVacetylation[1]
411DNFHFEVKDDFDFGTacetylation[1]
430IRGTVVMKDGNVIFPacetylation[1]
453KEAPAKQKTVAELEAacetylation[1]
768GKLQGILKSAPLLLPacetylation[1]
949YPIADLVKMLTEQGKacetylation[1]
956KMLTEQGKKVRFGIHacetylation[1]
1070AMLLGDAKKTCDALQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1086 AA 
Protein Sequence
MAHLLKTVVT GCLCPSVSNL GSCKVLPGKK DFLRTFRTHQ ALWCKSPAKP GIPYKQLTVG 60
VPKEIFQNEK RVALSPAGVQ ALVKQGFNVV VESGAGEASK FPDDLYRAAG AQIQGTKEVL 120
ASDLVVKVRA PMVNPTLGAH EADFLKPSGT LISFIYPAQN PDLLNKLSER KTTVLAMDQV 180
PRVTIAQGYD ALSSMANISG YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL 240
ASAGAAKSMG AVVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE 300
MKLFAQQCKE VDILISTALI PGKKAPVLFS KEMIESMKEG SVVVDLAAEA GGNFETTKPG 360
ELYVHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS PDKDNFHFEV KDDFDFGTMS 420
HVIRGTVVMK DGNVIFPAPT PKNIPKEAPA KQKTVAELEA EKAGTVSMYT KTLRTASVYS 480
AGLTGMLGLG IVAPNLAFSQ MVTTFGLAGI IGYHTVWGVT PALHSPLMSV TNAISGLTAV 540
GGLALMGGHF YPSTTSQSLA ALATFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL 600
PGGTFVGGYL AALYGGYNIE EIMYLGSGLC CVGALGGLST QGTARLGNAL GMIGVAGGLA 660
ATLGGLKPDP QLLAQMSGAM AMGGTIGLAI AKRIQISDLP QLVAAFHSLV GLAAVLTCMA 720
EYIVEYPHFA MDATSNFTKI VAYIGTYIGG VTFSGSLVAY GKLQGILKSA PLLLPGRHAL 780
NAGLLAASVG GIIPFMADPS FTTGIMCLGS VSALSTLMGV TLTAAIGGAD MPVVITVLNS 840
YSGWALCAEG FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG 900
KPMEISGTHT EINLDNAVEM IREANSIVIT PGYGLCAAKA QYPIADLVKM LTEQGKKVRF 960
GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINSDFPDT DLVLVIGAND TVNSAAQEDP 1020
NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA AVDNPIFYKP NTAMLLGDAK KTCDALQAKV 1080
RESYQK 1086 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0015992; P:proton transport; IEA:InterPro.
 GO:0072593; P:reactive oxygen species metabolic process; IEA:Compara. 
Interpro
 IPR008142; Ala_DH/PNT_CS1.
 IPR008143; Ala_DH/PNT_CS2.
 IPR007886; AlaDH/PNT_N.
 IPR007698; AlaDH/PNT_NAD(H)-bd.
 IPR012136; NADH_DH_b.
 IPR026255; NADP_transhyd_a.
 IPR024605; NADP_transhyd_a_C. 
Pfam
 PF01262; AlaDh_PNT_C
 PF05222; AlaDh_PNT_N
 PF12769; DUF3814
 PF02233; PNTB 
SMART
 SM01002; AlaDh_PNT_C
 SM01003; AlaDh_PNT_N 
PROSITE
 PS00836; ALADH_PNT_1
 PS00837; ALADH_PNT_2 
PRINTS