CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenomatosis polyposis coli 
Protein Synonyms/Alias
 Adenomatosis polyposis coli, isoform CRA_a; Adenomatous polyposis coli protein 
Gene Name
 Apc 
Gene Synonyms/Alias
 mCG_121500 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1684IQSGEFEKRDTIPTEacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2842 AA 
Protein Sequence
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 60
TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 120
FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 180
DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 240
ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 360
NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 420
WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGGL QAIAELLQVD 480
CEMYGLTNDH YSVTLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ 540
VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH RQILRENNCL 660
QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH SKHKMIAMGS 720
AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK 780
ASHRSKQRHK QNLYGDYAFD ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD 840
SSRSEKDRSL ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA KVEYKRSSND 960
SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA DLAHKIHSAN HMDDNDGELD 1020
TPINYSLKYS DEQLNSGRQS PSQNERWARP KHVIEDEIKQ NEQRQARSQN TSYPVYSENT 1080
DDKHLKFQPH FGQQECVSPY RSRGTSGSET NRMGSSHAIN QNVNQSLCQE DDYEDDKPTN 1140
YSERYSEEEQ HEEEEERPTN YSIKYNEEKH HVDQPIDYSL KYATDISSSQ KPSFSFSKNS 1200
SAQSTKPEHL SPSSENTAVP PSNAKRQNQL RPSSAQRNGQ TQKGTTCKVP SINQETIQTY 1260
CVEDTPICFS RCSSLSSLSS ADDEIGCDQT TQEADSANTL QTAEVKENDV TRSAEDPATE 1320
VPAVSQNARA KPSRLQASGL SSESTRHNKA VEFSSGAKSP SKSGAQTPKS PPEHYVQETP 1380
LVFSRCTSVS SLDSFESRSI ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP 1440
PPQTVQAKRE VPKSKVPAAE KRESGPKQTA VNAAVQRVQV LPDVDTLLHF ATESTPDGFS 1500
CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEESNENQDK EVEKPDSEKD 1560
LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP PPVARKPSQL PVYKLLPAQN 1620
RLQAQKHVSF TPGDDVPRVY CVEGTPINFS TATSLSDLTI ESPPNELATG DGVRAGIQSG 1680
EFEKRDTIPT EGRSTDDAQR GKISSIVTPD LDDNKAEEGD ILAECINSAM PKGKSHKPFR 1740
VKKIMDQVQQ ASSTSSGANK NQVDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1800
ETFSDNKDSK KPSLQTNAKA FNEKLPNNED RVRGSFALDS PHHYTPIEGT PYCFSRNDSL 1860
SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCRPEPNS SQQAASKSQA SIKHPANRAQ 1920
SKPVLQKQPT FPQSSKDGPD RGAATDEKLQ NFAIENTPVC FSRNSSLSSL SDIDQENNNN 1980
KESEPIKEAE PANSQGEPSK PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE 2040
CISSAMPKKK RPSRLKSESE KQSPRKVGGI LAEDLTLDLK DLQRPDSEHA FSPDSENFDW 2100
KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GISLGSPFHL TPDQEEKPFT 2160
SNKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT GKIRSNSEIS SQMKQPLPTN 2220
MPSISRGRTM IHIPGLRNSS SSTSPVSKKG PPLKTPASKS PSEGPGATTS PRGTKPAGKS 2280
ELSPITRQTS QISGSNKGSS RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISPPN 2340
KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQLSQQNLTK QASLSKNASS IPRSESASKG 2400
LNQMSNGNGS NKKVELSRMS STKSSGSESD RSERPALVRQ STFIKEAPSP TLRRKLEESA 2460
SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ AGGWRKLPPN LSPTIEYNDG 2520
RPTKRHDIAR SHSESPSRLP INRAGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES 2580
SEKAKSEDER HVSSMPAPRQ MKENQVPTKG TWRKIKESDI SPTGMASQSA SSGAASGAES 2640
KPLIYQMAPP VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDT 2700
HGKQSVGSGS PVQTVGLETR LNSFVQVEAP EQKGTEAKPG QSNPVSIAET AETCIAERTP 2760
FSSSSSSKHS SPSGTVAARV TPFNYNPSPR KSSADSTSAR PSQIPTPVST NTKKRDSKTD 2820
STESSGAQSP KRHSGSYLVT SV 2842 
Gene Ontology
 GO:0044295; C:axonal growth cone; IDA:MGI.
 GO:0030877; C:beta-catenin destruction complex; IEA:Compara.
 GO:0031253; C:cell projection membrane; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005881; C:cytoplasmic microtubule; IDA:MGI.
 GO:0000776; C:kinetochore; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0035371; C:microtubule plus end; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0008013; F:beta-catenin binding; IDA:MGI.
 GO:0051010; F:microtubule plus-end binding; IDA:MGI.
 GO:0019887; F:protein kinase regulator activity; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0009798; P:axis specification; IMP:MGI.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:MGI.
 GO:0007050; P:cell cycle arrest; IEA:InterPro.
 GO:0016477; P:cell migration; IMP:MGI.
 GO:0051276; P:chromosome organization; IMP:MGI.
 GO:0031122; P:cytoplasmic microtubule organization; IGI:MGI.
 GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0001822; P:kidney development; IMP:MGI.
 GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IMP:MGI.
 GO:0000281; P:mitotic cytokinesis; IMP:MGI.
 GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Compara.
 GO:0046716; P:muscle cell homeostasis; IGI:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:MGI.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Compara.
 GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development; IMP:MGI.
 GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.
 GO:0007026; P:negative regulation of microtubule depolymerization; IMP:MGI.
 GO:0042483; P:negative regulation of odontogenesis; IMP:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
 GO:0045785; P:positive regulation of cell adhesion; IMP:MGI.
 GO:0051781; P:positive regulation of cell division; IMP:MGI.
 GO:0030335; P:positive regulation of cell migration; IMP:MGI.
 GO:0030858; P:positive regulation of epithelial cell differentiation; IGI:MGI.
 GO:0031116; P:positive regulation of microtubule polymerization; IMP:MGI.
 GO:0045732; P:positive regulation of protein catabolic process; IMP:MGI.
 GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; IMP:MGI.
 GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; IMP:MGI.
 GO:0051726; P:regulation of cell cycle; IMP:MGI.
 GO:0051171; P:regulation of nitrogen compound metabolic process; IMP:MGI.
 GO:0045667; P:regulation of osteoblast differentiation; IMP:MGI.
 GO:0045670; P:regulation of osteoclast differentiation; IMP:MGI.
 GO:0006974; P:response to DNA damage stimulus; IEA:InterPro.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0035019; P:somatic stem cell maintenance; IMP:MGI.
 GO:0033077; P:T cell differentiation in thymus; IMP:MGI.
 GO:0048538; P:thymus development; IMP:MGI. 
Interpro
 IPR026836; APC.
 IPR009240; APC_15aa_rpt.
 IPR009234; APC_basic_dom.
 IPR009223; APC_Cys-rich_rpt.
 IPR026831; APC_dom.
 IPR026818; Apc_fam.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo.
 IPR009232; EB1-bd.
 IPR009224; SAMP. 
Pfam
 PF05972; APC_15aa
 PF05956; APC_basic
 PF05923; APC_crr
 PF00514; Arm
 PF05937; EB1_binding
 PF05924; SAMP
 PF11414; Suppressor_APC 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS