CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transporter 
Protein Synonyms/Alias
  
Gene Name
 Slc6a12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18SLSSMDRKVAVHEDGubiquitination[1]
42EGEMMDQKGKDQVKDubiquitination[1]
616NCSSSPAKQELIAWEubiquitination[1]
624QELIAWEKETHL***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 628 AA 
Protein Sequence
MSSRAWEERA SLSSMDRKVA VHEDGYPVVS WVPEEGEMMD QKGKDQVKDR GQWTNKMEFV 60
LSVAGEIIGL GNVWRFPYLC YKNGGGAFFI PYFIFFFSCG IPVFFLEVAL GQYSSQGSVT 120
AWRKICPLLQ GIGMASVVIE SYLNIYYIII LAWALFYLFS SFTWELPWTT CTNSWNTEHC 180
VDFLNHSSAR GVSSSENFTS PVMEFWERRV LGITSGIHDL GSLRWELALC LLLAWIICYF 240
CIWKGVKSTG KVVYFTATFP YLMLIILLIR GVTLPGAYQG IVFYLKPDLL RLKDPQVWMD 300
AGTQIFFSFA ICQGCLTALG SYNKYHNNCY RDSIALCFLN SATSFVAGFV VFSILGFMSQ 360
EQGIPISEVA ESGPGLAFIA FPKAVTMMPL SQLWSCLFFI MLLFLGLDSQ FVCMECLVTA 420
SMDMFPQQLR KSGRRELLIL AISVLCYLMG LLLVTEGGMY IFQLFDYYAS SGICLLFLSL 480
FEVICIGWVY GADRFYDNVE DMIGYRPWPL VKISWLFLTP GLCLATFFFS LSKYTPLKYN 540
NVYMYPSWGY SIGWLLAFSS MACVPLFIII TFLKTQGSFK KRLRRLITPD PSLPQPGRRP 600
PQDGSSAQNC SSSPAKQELI AWEKETHL 628 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:InterPro.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0071474; P:cellular hyperosmotic response; IEA:Compara.
 GO:0009992; P:cellular water homeostasis; IEA:Compara.
 GO:0010033; P:response to organic substance; IEA:Compara. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002983; Na/ntran_symport_betaine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01198; BETTRANSPORT.
 PR00176; NANEUSMPORT.