CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016142
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lambda-crystallin homolog 
Protein Synonyms/Alias
 L-gulonate 3-dehydrogenase; Gul3DH 
Gene Name
 Cryl1 
Gene Synonyms/Alias
 Cry 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
33ASGGFKVKLYDIEQQacetylation[1]
54ESIRKEMKSLEQSGSacetylation[1]
103PENLELKKKIFAQLDacetylation[1]
104ENLELKKKIFAQLDRacetylation[1]
177DRTYALMKKIRQTPVacetylation[1]
188QTPVRVLKEIDGFVLacetylation[1]
264EGMKRVLKTFGPVPEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 NP_BIND 16 17 NAD (By similarity).
 BINDING 36 36 NAD (By similarity).
 BINDING 97 97 NAD (By similarity).
 BINDING 102 102 NAD (By similarity).  
Keyword
 Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MASPAAGGVV IIGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITNALESIR KEMKSLEQSG 60
SLKGSLGAEQ QLSLISGCGN LAEAVEGAMH IQECVPENLE LKKKIFAQLD RIVDDQVILS 120
SSSSCLLPSK LFTGLAHVKQ CIVAHPVNPP YYVPLVELVP HPETAPATMD RTYALMKKIR 180
QTPVRVLKEI DGFVLNRLQY AIISEAWRLV EEGIVSPNDL DLVMSDGLGM RYAFIGPLET 240
MHLNAEGMVS YCDRYSEGMK RVLKTFGPVP EFSGDTVEKV NQDMCMKVPD DPEHLAARRH 300
WRDDCLMQLS KLKHQMQPQ 319 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050104; F:L-gulonate 3-dehydrogenase activity; ISS:UniProtKB.
 GO:0070403; F:NAD+ binding; ISS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:InterPro. 
Interpro
 IPR022694; 3-OHacyl-CoA_DH.
 IPR006180; 3-OHacyl-CoA_DH_CS.
 IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
 IPR006108; 3HC_DH_C.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00725; 3HCDH
 PF02737; 3HCDH_N 
SMART
  
PROSITE
 PS00067; 3HCDH 
PRINTS