UniProt Accession

 ENDD1_HUMAN; O94919; Q6GQY5; Q8TAQ8 

Genbank Protein ID

 AB020637; BC026191; BC071171 

Genbank Nucleotide ID

 BAA74853.1; AAH26191.1; AAH71171.1 

Protein Name

 Endonuclease domain-containing 1 protein 

Protein Synonyms/Alias

  

Gene Name

 ENDOD1 

Gene Synonyms/Alias

 KIAA0830 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
300	ERMVQSQKSSSPLSS	ubiquitination	[1]
407	KVLKVVAKVIRALLR	acetylation	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 May act as a DNase and a RNase (Potential). 

Sequence Annotation

 MOD_RES 407 407 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Endonuclease; Hydrolase; Nuclease; Polymorphism; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 500 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 

Interpro

 IPR001604; DNA/RNA_non-sp_Endonuclease.
 IPR020821; Extracellular_endonuc_su_A. 

Pfam

 PF01223; Endonuclease_NS 

SMART

 SM00892; Endonuclease_NS
 SM00477; NUC 

PROSITE

  

PRINTS