CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023311
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Brain-specific angiogenesis inhibitor 1-associated protein 2 
Protein Synonyms/Alias
 BAI-associated protein 2; BAI1-associated protein 2; Protein BAP2; Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53/p58; IRS-58; IRSp53/58; Insulin receptor substrate protein of 53 kDa; IRSp53; Insulin receptor substrate p53 
Gene Name
 BAIAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70ASESQGSKELGDVLFubiquitination[1]
160NPQKYSDKELQYIDAubiquitination[1, 2]
171YIDAISNKQGELENYubiquitination[1]
184NYVSDGYKTALTEERubiquitination[1]
275SDPIPGAKPLPVPPEubiquitination[1]
332SPPQSQSKLSDSYSNubiquitination[1]
359SYATTENKTLPRSSSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. 
Sequence Annotation
 DOMAIN 1 250 IMD.
 DOMAIN 374 437 SH3.
 MOD_RES 296 296 Phosphothreonine.
 MOD_RES 323 323 Phosphoserine.
 MOD_RES 325 325 Phosphoserine.
 MOD_RES 340 340 Phosphothreonine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 452 452 Phosphoserine (By similarity).
 MOD_RES 453 453 Phosphoserine (By similarity).
 MOD_RES 454 454 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 552 AA 
Protein Sequence
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK GYFDALVKMG 60
ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL 120
KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS 180
DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPSKIPERA 240
VQLMQQVASN GATLPSALSA SKSNLVISDP IPGAKPLPVP PELAPFVGRM SAQESTPIMN 300
GVTGPDGEDY SPWADRKAAQ PKSLSPPQSQ SKLSDSYSNT LPVRKSVTPK NSYATTENKT 360
LPRSSSMAAG LERNGRMRVK AIFSHAAGDN STLLSFKEGD LITLLVPEAR DGWHYGESEK 420
TKMRGWFPFS YTRVLDSDGS DRLHMSLQQG KSSSTGNLLD KDDLAIPPPD YGAASRAFPA 480
QTASGFKQRP YSVAVPAFSQ GLDDYGARSM SRNPFAHVQL KPTVTNDRCD LSAQGPEGRE 540
HGDGSARTLA GR 552 
Gene Ontology
 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0008093; F:cytoskeletal adaptor activity; TAS:ProtInc.
 GO:0070064; F:proline-rich region binding; IDA:UniProtKB.
 GO:0008022; F:protein C-terminus binding; TAS:ProtInc.
 GO:0051764; P:actin crosslink formation; ISS:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
 GO:0007409; P:axonogenesis; TAS:ProtInc.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0046847; P:filopodium assembly; IEA:InterPro.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:ProtInc.
 GO:0032956; P:regulation of actin cytoskeleton organization; IMP:UniProtKB.
 GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0009617; P:response to bacterium; IMP:UniProtKB. 
Interpro
 IPR013606; IRSp53/MIM_homology_IMD.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF08397; IMD
 PF07653; SH3_2 
SMART
 SM00326; SH3 
PROSITE
 PS51338; IMD
 PS50002; SH3 
PRINTS