CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 M18 aspartyl aminopeptidase 
Protein Synonyms/Alias
  
Gene Name
 PfM18AAP 
Gene Synonyms/Alias
 PFI1570c 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
210TILTTDTKFSHKENSacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 3D-structure; Aminopeptidase; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MDKKAREYAQ DALKFIQRSG SNFLACKNLK ERLENNGFIN LSEGETWNLN KNEGYVLCKE 60
NRNICGFFVG KNFNIDTGSI LISIGHIDSC ALKISPNNNV IKKKIHQINV ECYGSGLWHT 120
WFDRSLGLSG QVLYKKGNKL VEKLIQINKS VLFLPSLAIH LQNRTRYDFS VKINYENHIK 180
PIISTTLFNQ LNKCKRNNVH HDTILTTDTK FSHKENSQNK RDDQMCHSFN DKDVSNHNLD 240
KNTIEHLTNQ QNEEKNKHTK DNPNSKDIVE HINTDNSYPL LYLLSKELNC KEEDILDFEL 300
CLMDTQEPCF TGVYEEFIEG ARFDNLLGSF CVFEGFIELV NSIKNHTSNE NTNHTNNITN 360
DINDNIHNNL YISIGYDHEE IGSLSEVGAR SYCTKNFIDR IISSVFKKEI HEKNLSVQEI 420
YGNLVNRSFI LNVDMAHCSH PNYPETVQDN HQLFFHEGIA IKYNTNKNYV TSPLHASLIK 480
RTFELYYNKY KQQIKYQNFM VKNDTPCGST VGSMVAANLS MPGIDIGIPQ LAMHSIREIA 540
AVHDVFFLIK GVFAFYTYYN QVLSTCVHDK 570 
Gene Ontology
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001948; Peptidase_M18.
 IPR023358; Peptidase_M18_dom2. 
Pfam
 PF02127; Peptidase_M18 
SMART
  
PROSITE
  
PRINTS
 PR00932; AMINO1PTASE.