UniProt Accession

 APOA2_MOUSE; P09813; Q3UKX6; Q61317 

Genbank Protein ID

 X04119; M32360; M79361; M79362; X62772; AK145823; AC084821; CH466520; CH466520; CH466520; CH466520; BC031786 

Genbank Nucleotide ID

 CAA27731.1; AAA37248.1; AAA37249.1; AAA37250.1; CAA44616.1; BAE26675.1; EDL39118.1; EDL39119.1; EDL39120.1; EDL39121.1; AAH31786.1 

Protein Name

 Apolipoprotein A-II 

Protein Synonyms/Alias

 Apo-AII; ApoA-II; Apolipoprotein A2 

Gene Name

 Apoa2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
51	YGKDLMEKAKTSEIQ	ubiquitination	[1]
62	SEIQSQAKAYFEKTH	ubiquitination	[1]
67	QAKAYFEKTHEQLTP	acetylation	[2]
67	QAKAYFEKTHEQLTP	ubiquitination	[1]
96	SLMNLEEKPAPAAK*	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. 

Sequence Annotation

 MOD_RES 24 24 Pyrrolidone carboxylic acid (By  

Keyword

 Amyloid; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; HDL; Lipid transport; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0034366; C:spherical high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0015485; F:cholesterol binding; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0008035; F:high-density lipoprotein particle binding; IMP:MGI.
 GO:0055102; F:lipase inhibitor activity; IEA:Compara.
 GO:0031210; F:phosphatidylcholine binding; IEA:Compara.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0002526; P:acute inflammatory response; IEA:Compara.
 GO:0015759; P:beta-glucoside transport; NAS:UniProtKB.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IDA:MGI.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0046340; P:diacylglycerol catabolic process; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; NAS:UniProtKB.
 GO:0034380; P:high-density lipoprotein particle assembly; IEA:Compara.
 GO:0034384; P:high-density lipoprotein particle clearance; IEA:Compara.
 GO:0034375; P:high-density lipoprotein particle remodeling; IEA:Compara.
 GO:0006869; P:lipid transport; IMP:MGI.
 GO:0042157; P:lipoprotein metabolic process; IDA:MGI.
 GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0060621; P:negative regulation of cholesterol import; IEA:Compara.
 GO:0060695; P:negative regulation of cholesterol transporter activity; IEA:Compara.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Compara.
 GO:0060192; P:negative regulation of lipase activity; IMP:MGI.
 GO:0050995; P:negative regulation of lipid catabolic process; IEA:Compara.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0018206; P:peptidyl-methionine modification; IEA:Compara.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:Compara.
 GO:0009395; P:phospholipid catabolic process; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISS:UniProtKB.
 GO:0050996; P:positive regulation of lipid catabolic process; IEA:Compara.
 GO:0006457; P:protein folding; IEA:Compara.
 GO:0018158; P:protein oxidation; IEA:Compara.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IMP:MGI.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IEA:Compara. 

Interpro

 IPR006801; ApoA-II. 

Pfam

 PF04711; ApoA-II 

SMART

  

PROSITE

  

PRINTS