UniProt Accession

 TIMP3_HUMAN; P35625; B2RBY9; Q5THV4; Q9UC74; Q9UGS2 

Genbank Protein ID

 X76227; S78453; U14394; U02571; Z30183; U33114; U33110; U33111; U33112; U33113; U67195; CR456593; BT006848; AK314871; AL023282; Z98256; Z98256; AL023282; CH471095; BC014277; L15078; U38955; U38952; U38953; U38954 

Genbank Nucleotide ID

 CAA53813.1; AAB34532.1; AAB60373.1; AAA17672.1; CAA82918.1; AAC50393.1; AAC50393.1; AAC50393.1; AAC50393.1; AAC50393.1; AAB07547.1; CAG30479.1; AAP35494.1; BAG37386.1; CAI17996.1; CAI17996.1; CAI20115.1; CAI20115.1; EAW60038.1; AAH14277.1; AAA21815.1; AAB17602.1; AAB17602.1; AAB17602.1; AAB17602.1 

Protein Name

 Metalloproteinase inhibitor 3 

Protein Synonyms/Alias

 Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 

Gene Name

 TIMP3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	GLKLEVNKYQYLLTG	acetylation	[1]

Reference

 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. 

Sequence Annotation

 DOMAIN 24 143 NTR.
 REGION 24 28 Involved in metalloproteinase-binding.
 REGION 88 89 Involved in metalloproteinase-binding.
 REGION 105 188 Mediates interaction with EFEMP1.
 METAL 24 24 Zinc; via amino nitrogen and carbonyl
 DISULFID 24 91
 DISULFID 26 118
 DISULFID 36 143
 DISULFID 145 192 By similarity.
 DISULFID 150 155 By similarity.
 DISULFID 163 184 By similarity.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Extracellular matrix; Metal-binding; Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor; Reference proteome; Secreted; Sensory transduction; Signal; Vision; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008191; F:metalloendopeptidase inhibitor activity; TAS:BHF-UCL.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 

Interpro

 IPR001134; Netrin_domain.
 IPR001820; Prot_inh_TIMP.
 IPR008993; TIMP-like_OB-fold.
 IPR027465; TIMP_C_dom.
 IPR015612; Tissue_inhib_metalloprotease_3. 

Pfam

 PF00965; TIMP 

SMART

 SM00206; NTR 

PROSITE

 PS50189; NTR
 PS00288; TIMP 

PRINTS