CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025618
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PIK4CA variant protein 
Protein Synonyms/Alias
  
Gene Name
 PIK4CA variant protein 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1768TNVSAIIKPYPKGDEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2121 AA 
Protein Sequence
GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY FNTVLSLARS 60
LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL GIFLIESDLQ HKDCVVPYLL 120
RLLKGLPKVY WVEESTARKG RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEVLLQVL 180
HVLLGMCQAL EIQDKEYLCK YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE 240
ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF 300
HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE LLNLVKKIVE 360
EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML RDTLYYMKDL PTSFVKEIHD 420
FVLEQFNTSQ GELQKILHDA DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK 480
LSEKLQSKTS SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL 540
YKYHSQYHTV AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL 600
TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP KVMEPILQIL 660
QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG 720
YRHCSLAVIN ALANIAANIQ DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS 780
SSAGNLGVLI PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE 840
GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL 900
INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD 960
KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL 1020
WSGTVLKTML DILQTLSLSL SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC 1080
GMILQEAMKW APTVTKSHLQ EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG 1140
ATQLSERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL 1200
DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK 1260
DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE ASQPKPCPPE VTPHYIWIDF 1320
LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH 1380
ADVVPNATIR NVLREKIYST AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL 1440
TASQLVPPDN QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL 1500
HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK 1560
DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA 1620
DAPELSHVLC WAPTDPPTGL SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL 1680
RYDKMGYVRE YILWAASKSQ LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG 1740
SLSGPAKDFY QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE 1800
AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE CSTQEADGQK 1860
ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD 1920
CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG 1980
NIMLDKKGHI IHIDFGFMFE SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV 2040
RGYLAVRPYM DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC 2100
FLSNRSRTYD MIQYYQNDIP Y 2121 
Gene Ontology
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00613; PI3Ka 
SMART
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51545; PIK_HELICAL 
PRINTS