UniProt Accession

 CAH2_BOVIN; P00921; Q3ZBJ5; Q865Y7 

Genbank Protein ID

 AY240020; BC103260 

Genbank Nucleotide ID

 AAO85140.1; AAI03261.1 

Protein Name

 Carbonic anhydrase 2 

Protein Synonyms/Alias

 Carbonate dehydratase II; Carbonic anhydrase II; CA-II 

Gene Name

 CA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
9	SHHWGYGKHNGPEHW	acetylation	[1]
18	NGPEHWHKDFPIANG	acetylation	[1]
36	SPVDIDTKAVVQDPA	acetylation	[1]
45	VVQDPALKPLALVYG	acetylation	[1]
76	EYDDSQDKAVLKDGP	acetylation	[1]
80	SQDKAVLKDGPLTGT	acetylation	[1]
112	SEHTVDRKKYAAELH	acetylation	[1]
113	EHTVDRKKYAAELHL	acetylation	[1]
126	HLVHWNTKYGDFGTA	acetylation	[1]
148	AVVGVFLKVGDANPA	acetylation	[1]
158	DANPALQKVLDALDS	acetylation	[1]
167	LDALDSIKTKGKSTD	acetylation	[1]
169	ALDSIKTKGKSTDFP	acetylation	[1]
171	DSIKTKGKSTDFPNF	acetylation	[1]
212	SVTWIVLKEPISVSS	acetylation	[1]
224	VSSQQMLKFRTLNFN	acetylation	[1]
251	WRPAQPLKNRQVRGF	acetylation	[1]
260	RQVRGFPK*******	acetylation	[1]

Reference

 [1] Eliminating positively charged lysine epsilon-NH3+ groups on the surface of carbonic anhydrase has no significant influence on its folding from sodium dodecyl sulfate.
 Gudiksen KL, Gitlin I, Yang J, Urbach AR, Moustakas DT, Whitesides GM.
 J Am Chem Soc. 2005 Apr 6;127(13):4707-14. [PMID: 15796537] 

Functional Description

 Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. 

Sequence Annotation

 REGION 198 199 Substrate binding (By similarity).
 ACT_SITE 64 64 Proton acceptor (By similarity).
 ACT_SITE 67 67 By similarity.
 ACT_SITE 127 127 By similarity.
 METAL 94 94 Zinc; catalytic.
 METAL 96 96 Zinc; catalytic.
 METAL 119 119 Zinc; catalytic.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Metal-binding; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004089; F:carbonate dehydratase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018440; Carbonic_anhydrase_CA2. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS