CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011105
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clustered mitochondria protein 1 
Protein Synonyms/Alias
 Translation initiation factor 31; eIF3-associated protein p135 
Gene Name
 CLU1 
Gene Synonyms/Alias
 TIF31; YMR012W; YM8270.16 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
96IKEIVGEKSELKLQLubiquitination[1]
106LKLQLILKPYSAREAacetylation[2]
269VNKSNSTKFDPSPKEubiquitination[1]
301LIASRSKKFISHVQAacetylation[2]
311SHVQAFEKKLSALDSacetylation[2]
632WWNNKVEKEGVEFEKacetylation[2]
766ERQAKINKLVQEGKEacetylation[2]
766ERQAKINKLVQEGKEubiquitination[1]
772NKLVQEGKEVPKELTubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in proper cytoplasmic distribution of mitochondria. 
Sequence Annotation
 REPEAT 704 738 TPR 1.
 REPEAT 1020 1053 TPR 2.
 REPEAT 1148 1181 TPR 3.
 MOD_RES 1247 1247 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1277 AA 
Protein Sequence
MSEKKEEVKN ATVKVTVKLP KEDNHSHNTK HLKKTQSSKN NDISFEIGKE SKIQTVLDVL 60
AMIPSSKYLT NVGLKTIEGD SQLSDEMSIK EIVGEKSELK LQLILKPYSA REALKHVITV 120
RDFIGFAQET SDGLSEFAIS TGSSFSSLPL GPIKERSKQE EKDEKSDPEE KKNTFKDVTD 180
EEKLKFNEMV HEVFSSFKNS SINKLLTSES NIITPCVRSL SFAPYNPVPP FYRSKGHLFY 240
LQIVTLEGES FYITAIPSGF YVNKSNSTKF DPSPKENTDE NAHSSLIYYS LFDLIASRSK 300
KFISHVQAFE KKLSALDSTS YVRPSNTFLH KPWFVSSLPP NNPDYLRLQT AALDTTPERN 360
FNDEFQAIKD LTTSTLQDRI EMERLFSKVV HEFSVTAASG AMSIFYSDFV AMNPESPTRD 420
QIFLKDNIFY SYVSDVSGNY EGKGGDEAAI AASNQDLKTI NILNRLHMHE VRYLLTTVVE 480
FAGRRILAQT PVPGLLATMG NKIVKDANTG EEVTEDFVND INVKYGLDEG LGKIVYDADF 540
DSVLEKKFVK AFHLKKHKVN GTELAFSSQS KGIVGFDKRR YILDLANTYP LDINFARQNF 600
DNIEETGNRY PHRQTLLRPE LVEKWWNNKV EKEGVEFEKA YEENLFSYNP DAYQVEGIED 660
ANVDEMSNYL QKEVIPSVIQ DYLSGNLSTP YNGEHLADTL HKNGINMRYL GKIIELSQKE 720
LDSQIVHYEQ NLKAVEQDNK EYEDWEKSYL QKIENMIKER QAKINKLVQE GKEVPKELTE 780
DLKLNDEEIK KPTDGKPVVV AYDELVPLIK ISELEIVSRS LKHVLKDLSK DVPVFLVPSL 840
VAYVFNMLVG INYNADPKPE PVDEFYPVNK CSFAKLTRSE LLEAVSKQAF LRFRHQLPSN 900
WIEAYMENPF TLIRSVSYKF GIQLLNKEYF FTREQLESYK QSLDKKIRNK FVEPPTTFSL 960
SDLTIIPRVK FSEYTSSVSE EFWAQGASMI NEDKQSALTL LAQSITVLED VNNILHPAVA 1020
EKYLSLSAIY NKLALYPEAI AFCRKACTIY ERVSGIDSFE MMRALTNLAI LEFSNESPYN 1080
ATVVYNRLAE ILKVYELPKI HHPAPTSIFN HLEQLALGVQ DTKLAIEVLG QLSSYVVELE 1140
GKDSLAYGYT ESRLGNLFAA LKDFHRALEH ITVTQGIFTK QLGMNHTHSA QSRQWVNGLS 1200
SLIMDLKQKK QLAQDQMSTT GSNSAGHKKT NHRQKKDDVK PELANKSVDE LLTFIEGDSS 1260
NSKSKNKTNN KKKHGKK 1277 
Gene Ontology
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IPI:SGD.
 GO:0048312; P:intracellular distribution of mitochondria; IEA:InterPro.
 GO:0007005; P:mitochondrion organization; IMP:SGD.
 GO:0006413; P:translational initiation; IPI:SGD. 
Interpro
 IPR027523; CLU.
 IPR025697; CLU_dom.
 IPR023231; GSKIP/TIF31_domain.
 IPR011990; TPR-like_helical. 
Pfam
 PF13236; CLU 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS