CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021789
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier organic anion transporter family member 1B2 
Protein Synonyms/Alias
 Liver-specific organic anion transporter 1; LST-1; SLC21A6; Solute carrier family 21 member 10 
Gene Name
 Slco1b2 
Gene Synonyms/Alias
 Oatp1b2; Slc21a10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9DQTQHPSKAAQPLRSubiquitination[1]
47ALGGVIMKSSITQIEubiquitination[1]
286KRSQKERKNSASLHVubiquitination[1]
295SASLHVLKTDEDKNPubiquitination[1]
300VLKTDEDKNPVTNPTacetylation[2]
300VLKTDEDKNPVTNPTubiquitination[1]
311TNPTTQEKQAPANLTubiquitination[1]
583RSVQPELKSLGMGFHubiquitination[1]
616LIDRTCMKWSVTSCGubiquitination[1]
672KMKRNDNKILENGRKubiquitination[1]
679KILENGRKFTDEGNPubiquitination[1]
702SCVPSDEKNSETPL*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2 (By similarity). 
Sequence Annotation
 DOMAIN 448 505 Kazal-like.
 MOD_RES 288 288 Phosphoserine.
 MOD_RES 290 290 Phosphoserine.
 CARBOHYD 132 132 N-linked (GlcNAc...) (Potential).
 CARBOHYD 140 140 N-linked (GlcNAc...) (Potential).
 CARBOHYD 513 513 N-linked (GlcNAc...) (Potential).
 DISULFID 454 480 By similarity.
 DISULFID 458 469 By similarity.
 DISULFID 460 484 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 689 AA 
Protein Sequence
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI TQIERRFDIP 60
SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF IMGIGSILTA LPHFFMGYYR 120
YATENDISSL HNSTLTCLVN QTTSLTGTSP EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE 180
TPIVPLGVSY IDDFAKEGNS SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV 240
RITPQDARWV GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK 300
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS FTYLFKFIEQ 360
QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTAK LYVDVGYVDL RSVRITPLLG 420
ITKFVFFTTT MAYVFYLSYF LLICENKAFA GLTLTYDGMN PVDSHIDVPL SYCNSDCICD 480
KNQWEPVCGE NGVTYISPCL AGCKSFRGDK KLMNIEFYDC SCVSGSGFQK GNHSARLGEC 540
PRDKCKTKYY FYITFQVIIS FFTALGSTSL MLILIRSVQP ELKSLGMGFH SLVVRTLGGI 600
LAPVYYGALI DRTCMKWSVT SCGARGACRL YNSRLFGMIY VGLSIALKTP ILLLYVALIY 660
VMKRKMKRND NKILENGRKF TDEGNPEPVN NNGYSCVPSD EKNSETPL 708 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; ISS:MGI.
 GO:0015125; F:bile acid transmembrane transporter activity; IEA:Compara.
 GO:0015238; F:drug transmembrane transporter activity; IEA:Compara.
 GO:0015198; F:oligopeptide transporter activity; IEA:Compara.
 GO:0008514; F:organic anion transmembrane transporter activity; ISS:MGI.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. 
Interpro
 IPR002350; Kazal_dom.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004156; OA_transporter. 
Pfam
 PF07648; Kazal_2
 PF03137; OATP 
SMART
 SM00280; KAZAL 
PROSITE
 PS51465; KAZAL_2
 PS50850; MFS 
PRINTS