| Tag | Content |
|---|
| CPLM ID | CPLM-022709 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Abl interactor 1 |
Protein Synonyms/Alias | Abelson interactor 1; Abi-1; Eps8 SH3 domain-binding protein; Eps8-binding protein; e3B1 |
Gene Name | Abi1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 45 | IQATDKRKALEETKA | acetylation | [1] | | 200 | YKTLEPVKPPTVPND | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity). |
Sequence Annotation | DOMAIN 45 107 t-SNARE coiled-coil homology.
DOMAIN 414 473 SH3.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 178 178 Phosphoserine (By similarity).
MOD_RES 208 208 Phosphotyrosine (By similarity).
MOD_RES 211 211 Phosphoserine (By similarity).
MOD_RES 217 217 Phosphoserine (By similarity).
MOD_RES 220 220 Phosphoserine (By similarity).
MOD_RES 291 291 Phosphoserine (By similarity).
MOD_RES 423 423 Phosphotyrosine (By similarity).
MOD_RES 475 475 Phosphothreonine (By similarity). |
Keyword | Acetylation; Cell junction; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Synaptosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS 60
VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 120
THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKHGNNQP ARTGTLSRTN PPTQKPPSPP 180
VSGRGTLGRN TPYKTLEPVK PPTVPNDYMT SPARLGSQHS PGRTASLNQR PRTHSGSSGG 240
SGSRENSGSS SIGIPIAVPT PSPPTAGPAA PGAAPGSQYG TMTRQISRHN STTSSTSSGG 300
YRRTPSVTAQ FSAQPHVNGG PLYSQNSISI APPPPPMPQL TPQIPLTGFV ARVQENIADS 360
PTPPPPPPPD DIPMFDDSPP PPPPPPVDYE DEEAAVVQYS DPYADGDPAW APKNYIEKVV 420
AIYDYTKDKD DELSFKEGAI IYVIKKNDDG WFEGVCNRVT GLFPGNYVES IMHYTD 476 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0030175; C:filopodium; IEA:UniProtKB-SubCell. GO:0030426; C:growth cone; IEA:UniProtKB-SubCell. GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0045202; C:synapse; IEA:UniProtKB-KW. GO:0030296; F:protein tyrosine kinase activator activity; IEA:Compara. GO:0006928; P:cellular component movement; IEA:Compara. GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara. GO:0001756; P:somitogenesis; IEA:Compara. |
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PRINTS | |