UniProt Accession

 GTAB_BACSU; Q05852 

Genbank Protein ID

 L12272; Z22516; AL009126 

Genbank Nucleotide ID

 AAA71967.1; CAA80241.1; CAB15584.1 

Protein Name

 UTP--glucose-1-phosphate uridylyltransferase 

Protein Synonyms/Alias

 Alpha-D-glucosyl-1-phosphate uridylyltransferase; General stress protein 33; GSP33; UDP-glucose pyrophosphorylase; UDPGP; Uridine diphosphoglucose pyrophosphorylase 

Gene Name

 gtaB 

Gene Synonyms/Alias

 BSU35670 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
273	LEFAMQDKELRDQLV	acetylation	[1]
289	FMEGLLNKEEI****	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Has a role in the biosynthesis of all phosphate-containing envelope polymers, since UDP-glucose serves as a glucosyl donor not only for the biosynthesis of LTA but also for wall teichoic acids (WTAs). Is required for biofilm formation. This is likely due to another role of UDP-glucose, which might also act as a metabolic signal regulating biofilm formation or may be involved in some unknown biosynthetic pathway essential for biofilm formation, e.g. the synthesis of an exopolysaccharide. 

Sequence Annotation

  

Keyword

 Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Nucleotidyltransferase; Reference proteome; Stress response; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:EC.
 GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro. 

Interpro

 IPR005771; GalU_uridylyltTrfase_bac/arc.
 IPR005835; NTP_transferase. 

Pfam

 PF00483; NTP_transferase 

SMART

  

PROSITE

  

PRINTS