CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030676
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NAD-dependent protein deacetylase sirtuin-6 
Protein Synonyms/Alias
 cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) 
Gene Name
 SIRT6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9EERGLAPKFDTTFESubiquitination[1]
56RSGFPRDKLAELHGNubiquitination[1]
88VVGTMGLKATGRLCTubiquitination[2]
98GRLCTVAKARGLRACubiquitination[1]
173IVNLQPTKHDRHADLubiquitination[1, 3]
195EVMTRLMKHLGLEIPubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 283 AA 
Protein Sequence
MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS GFPRDKLAEL 60
HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR GLRACRGELR DTILDWEDSL 120
PDRDLALADE ASRNADLSIT LGTSLQIRPS GNLPLATKRR GGRLVIVNLQ PTKHDRHADL 180
RIHGYVDEVM TRLMKHLGLE IPAWDGPRVL ERALPPLPRP PTPKLEPKEE SPTRINGSIP 240
AGPKQEPCAQ HNGSEPASPK RERPTSPAPH RPPKRVKAKA VPS 283 
Gene Ontology
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:Compara.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0006471; P:protein ADP-ribosylation; IEA:Compara. 
Interpro
 IPR003000; Sirtuin.
 IPR026590; Ssirtuin_cat_dom. 
Pfam
 PF02146; SIR2 
SMART
  
PROSITE
 PS50305; SIRTUIN 
PRINTS