CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019307
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PDZ and LIM domain protein 5 
Protein Synonyms/Alias
 Enigma homolog; Enigma-like PDZ and LIM domains protein 
Gene Name
 PDLIM5 
Gene Synonyms/Alias
 ENH; L9 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105GEPKEVVKPVPITSPacetylation[1]
305SEADNTKKANNSQEPubiquitination[2]
485ECGRCQRKILGEVISubiquitination[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). 
Sequence Annotation
 DOMAIN 2 85 PDZ.
 DOMAIN 418 477 LIM zinc-binding 1.
 DOMAIN 477 536 LIM zinc-binding 2.
 DOMAIN 536 596 LIM zinc-binding 3.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 111 111 Phosphoserine.
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 228 228 Phosphoserine (By similarity).
 MOD_RES 309 309 Phosphoserine.
 MOD_RES 313 313 Phosphoserine.
 MOD_RES 335 335 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; LIM domain; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Repeat; Synapse; Synaptosome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 596 AA 
Protein Sequence
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV LSIDGINAQG 60
MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP KEVVKPVPIT SPAVSKVTST 120
NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF TPAHATTSSH ASPSPVAAVT PPLFAASGLH 180
ANANLSADQS PSALSAGKTA VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR 240
KHIVERYTEF YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA 300
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK PVGSTGVIKS 360
PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD QDTLVQRAEH IPAGKRTPMC 420
AHCNQVIRGP FLVALGKSWH PEEFNCAHCK NTMAYIGFVE EKGALYCELC YEKFFAPECG 480
RCQRKILGEV ISALKQTWHV SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG 540
CEFPIEAGDM FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF 596 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:LIFEdb.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0016020; C:membrane; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0042805; F:actinin binding; ISS:UniProtKB.
 GO:0005080; F:protein kinase C binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
 GO:0051963; P:regulation of synapse assembly; ISS:UniProtKB. 
Interpro
 IPR001478; PDZ.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF00595; PDZ 
SMART
 SM00132; LIM
 SM00228; PDZ 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50106; PDZ 
PRINTS